Replimune Group
REPL
163 hedge funds and large institutions have $348M invested in Replimune Group in 2025 Q3 according to their latest regulatory filings, with 38 funds opening new positions, 61 increasing their positions, 47 reducing their positions, and 49 closing their positions.
207% more call options, than puts
Call options by funds: $41.2M | Put options by funds: $13.4M
30% more repeat investments, than reductions
Existing positions increased: 61 | Existing positions reduced: 47
1.16% more ownership
Funds ownership: 105.02% → 106.18% (+1.2%)
6% less funds holding
Funds holding: 174 → 163 (-11)
22% less first-time investments, than exits
New positions opened: 38 | Existing positions closed: 49
54% less capital invested
Capital invested by funds: $752M → $348M (-$405M)
86% less funds holding in top 10
Funds holding in top 10: 7 → 1 (-6)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RI
RTW Investments
New York
|
+$27.7M |
| 2 |
Point72 Asset Management
Stamford,
Connecticut
|
+$18.6M |
| 3 |
RAM
Readystate Asset Management
Chicago,
Illinois
|
+$15.5M |
| 4 |
B
Braidwell
Stamford,
Connecticut
|
+$14.9M |
| 5 |
Balyasny Asset Management
Chicago,
Illinois
|
+$14M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RG
Redmile Group
San Francisco,
California
|
-$26.4M |
| 2 |
Marshall Wace
London,
United Kingdom
|
-$17.3M |
| 3 |
SI
Sofinnova Investments
Menlo Park,
California
|
-$16.8M |
| 4 |
T. Rowe Price Associates
Baltimore,
Maryland
|
-$16.1M |
| 5 |
OFM
Omega Fund Management
Boston,
Massachusetts
|
-$11M |
REPL Hedge Fund Activity: Q3 2025 in Review
163 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Replimune Group (REPL) for Q3 2025, worth a combined $348M — down 54% from $752M a quarter earlier.
Sellers outnumbered buyers: 49 funds closed out of REPL and 38 opened new positions — a net loss of 11 holders — while 47 trimmed existing stakes and 61 added.
The largest buyer was RTW Investments, adding an estimated $27.7M. The largest seller was Redmile Group, cutting an estimated $26.4M.
- 163 institutional investors held Replimune Group (REPL) as of Q3 2025, down from 174 in Q2 2025.
- Funds reported $348M of Replimune Group stock for Q3 2025, down 54% quarter-over-quarter.
- 38 funds opened new Replimune Group positions in Q3 2025 and 49 closed out, a net change of -11 holders.
- The largest Replimune Group buyer in Q3 2025 was RTW Investments, an estimated $27.7M added.
- The largest Replimune Group seller in Q3 2025 was Redmile Group, an estimated $26.4M sold.
Based on aggregated 13F filings for Q3 2025.