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Q32 Bio
QTTB

52 hedge funds and large institutions have $26.7M invested in Q32 Bio in 2025 Q4 according to their latest regulatory filings, with 7 funds opening new positions, 9 increasing their positions, 20 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

60% more capital invested

Capital invested by funds: $16.6M → $26.7M (+$10M)

0% more funds holding in top 10

Funds holding in top 10: 4 → 4 (0)

2% less funds holding

Funds holding: 53 → 52 (-1)

3.73% less ownership

Funds ownership: 69.1% → 65.37% (-3.7%)

13% less first-time investments, than exits

New positions opened: 7 | Existing positions closed: 8

55% less repeat investments, than reductions

Existing positions increased: 9 | Existing positions reduced: 20

Holders
52
Holders Change
-1
Holders Change %
-1.89%
% of All Funds
0.63%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
7
Increased
9
Reduced
20
Closed
8
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
OM
Opaleye Management
Massachusetts
+$603K
2
Renaissance Technologies
Renaissance Technologies
New York
+$148K
3
Citadel Advisors
Citadel Advisors
Florida
+$101K
4
Vanguard Group
Vanguard Group
Pennsylvania
+$72.5K
5
Jane Street
Jane Street
New York
+$71.7K

Top Sellers

Rank Fund Capital Flow
1
ACA
Acorn Capital Advisors
New York
-$876K
2
MAM
Monaco Asset Management
Monaco
-$735K
3
TOCUITCONY
Trustees of Columbia University in the City of New York
New York
-$265K
4
Millennium Management
Millennium Management
New York
-$151K
5
BlackRock
BlackRock
New York
-$93.5K
Name Holding Trade Value Shares
Change 		Change in
Stake
UBS Group
26
UBS Group
Switzerland
$45.2K +$23.6K +8,360 +159%
Morgan Stanley
27
Morgan Stanley
New York
$18.2K -$16.6K -5,865 -52%
EWA
28
EverSource Wealth Advisors
Alabama
$15.4K -$1.09K -385 -8%
Fidelity Investments
29
Fidelity Investments
Massachusetts
$11.2K -$35.3K -12,503 -79%
Federated Hermes
30
Federated Hermes
Pennsylvania
$7.55K -$285 -101 -4%
GRP
31
Global Retirement Partners
California
$4.98K -$9.89K -3,500 -70%
AAP
32
Arax Advisory Partners
Colorado
$3.69K -$294 -104 -9%
Bank of America
33
Bank of America
North Carolina
$3.44K -$1.39K -490 -32%
TRCT
34
Tower Research Capital (TRC)
New York
$3.24K -$15.6K -5,506 -85%
Rockefeller Capital Management
35
Rockefeller Capital Management
New York
$1.92K – – –
Jones Financial Companies
36
Jones Financial Companies
Missouri
$1.66K +$1.41K +500 New
Russell Investments Group
37
Russell Investments Group
United Kingdom
$1.51K – – –
JP Morgan Chase
38
JP Morgan Chase
New York
$1.08K +$904 +320 +8,000%
BNP Paribas Financial Markets
39
BNP Paribas Financial Markets
France
$1.02K -$350 -124 -29%
Royal Bank of Canada
40
Royal Bank of Canada
Ontario, Canada
$1K -$2.31K -818 -78%
Nisa Investment Advisors
41
Nisa Investment Advisors
Missouri
$551 – – –
SS
42
SBI Securities
Japan
$521 -$22.6K -7,999 -98%
Osaic Holdings
43
Osaic Holdings
Arizona
$437 -$155 -55 -29%
AF
44
Allworth Financial
California
$326 -$1.45K -512 -84%
FDCDDQ
45
Federation des caisses Desjardins du Quebec
Quebec, Canada
$231 – – –
Group One Trading
46
Group One Trading
Illinois
$113 – – –
Northwestern Mutual Wealth Management
47
Northwestern Mutual Wealth Management
Wisconsin
$100 +$85 +30 New
Barclays
48
Barclays
United Kingdom
$63 -$2.27K -803 -98%
HI
49
Harbour Investments
Wisconsin
$37 – – –
AF
50
Advisornet Financial
Minnesota
$7 – – –
1
2
3

QTTB Hedge Fund Activity: Q4 2025 in Review

52 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Q32 Bio (QTTB) for Q4 2025, worth a combined $26.7M — up 60% from $16.6M a quarter earlier.

Sellers outnumbered buyers: 8 funds closed out of QTTB and 7 opened new positions — a net loss of 1 holder — while 20 trimmed existing stakes and 9 added.

The largest buyer was Opaleye Management, opening a new position worth an estimated $603K. The largest seller was Acorn Capital Advisors, cutting an estimated $876K.

  • 52 institutional investors held Q32 Bio (QTTB) as of Q4 2025, down from 53 in Q3 2025.
  • Funds reported $26.7M of Q32 Bio stock for Q4 2025, up 60% quarter-over-quarter.
  • 7 funds opened new Q32 Bio positions in Q4 2025 and 8 closed out, a net change of -1 holder.
  • The largest Q32 Bio buyer in Q4 2025 was Opaleye Management, an estimated $603K added.
  • The largest Q32 Bio seller in Q4 2025 was Acorn Capital Advisors, an estimated $876K sold.

Based on aggregated 13F filings for Q4 2025.