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Prothena Corp
PRTA

Overview Fund Activity

159 hedge funds and large institutions have $647M invested in Prothena Corp in 2025 Q1 according to their latest regulatory filings, with 17 funds opening new positions, 42 increasing their positions, 58 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
159
Holders Change
-10
Holders Change %
-5.92%
% of All Funds
2.16%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
17
Increased
42
Reduced
58
Closed
25
Calls
$3.5M
Puts
$1.25M
Net Calls
+$2.25M
Net Calls Change
-$2.23M

Top Buyers

1
Nordea Investment Management
Nordea Investment Management
Sweden
+$3.74M
2
SL
Siren LLC
Connecticut
+$2.27M
3
DA
DCF Advisers
Connecticut
+$1.13M
4
Jane Street
Jane Street
New York
+$954K
5
Wellington Management Group
Wellington Management Group
Massachusetts
+$850K

Top Sellers

1
State Street
State Street
Massachusetts
-$4.21M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$2.84M
3
Federated Hermes
Federated Hermes
Pennsylvania
-$2.47M
4
RSCM
Rock Springs Capital Management
Maryland
-$1.88M
5
Axa
Axa
France
-$1.67M
Name Holding Trade Value Shares
Change 		Shares
Change %
EC
1
EcoR1 Capital
California
$143M – – –
Fidelity Investments
2
Fidelity Investments
Massachusetts
$98.3M -$1.61M -129,907 -2%
Wellington Management Group
3
Wellington Management Group
Massachusetts
$64.3M +$850K +68,652 +1%
BlackRock
4
BlackRock
New York
$50M -$991K -80,075 -2%
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$42.8M -$2.84M -229,852 -6%
AC
6
Armistice Capital
New York
$27.2M -$495K -40,000 -2%
PAI
7
Palo Alto Investors
California
$20.5M -$968K -78,230 -5%
State Street
8
State Street
Massachusetts
$18.8M -$4.21M -340,277 -18%
SL
9
Siren LLC
Connecticut
$15.9M +$2.27M +183,715 +17%
Vanguard Group
10
Vanguard Group
Pennsylvania
$15.7M -$1.67M -134,567 -10%
Geode Capital Management
11
Geode Capital Management
Massachusetts
$12.6M +$625K +50,484 +5%
Dimensional Fund Advisors
12
Dimensional Fund Advisors
Texas
$10.7M -$20.9K -1,685 -0.2%
Morgan Stanley
13
Morgan Stanley
New York
$8.91M +$6.16K +498 +0.1%
BCM
14
Boxer Capital Management
California
$8.54M – – –
FC
15
Finepoint Capital
Massachusetts
$7.92M -$210K -17,000 -3%
Federated Hermes
16
Federated Hermes
Pennsylvania
$6.76M -$2.47M -199,922 -27%
Goldman Sachs
17
Goldman Sachs
New York
$6.32M -$570K -46,064 -8%
RSCM
18
Rock Springs Capital Management
Maryland
$6.1M -$1.88M -152,000 -24%
PM
19
Prosight Management
Texas
$5.05M -$124K -10,000 -2%
UBS AM
20
UBS AM
Illinois
$4.72M +$1.78K +144 +0%
Northern Trust
21
Northern Trust
Illinois
$4.62M -$381K -30,793 -8%
JPMorgan Chase & Co
22
JPMorgan Chase & Co
New York
$4.6M -$190K -15,385 -4%
Mariner
23
Mariner
Kansas
$4.39M +$133K +10,733 +3%
BC
24
Birchview Capital
Vermont
$4.12M +$351K +28,400 +9%
Charles Schwab
25
Charles Schwab
California
$3.96M -$93.4K -7,544 -2%
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