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Prothena Corp
PRTA

161 hedge funds and large institutions have $647M invested in Prothena Corp in 2025 Q1 according to their latest regulatory filings, with 16 funds opening new positions, 42 increasing their positions, 59 reducing their positions, and 24 closing their positions.

New
Increased
Maintained
Reduced
Closed

180% more call options, than puts

Call options by funds: $3.5M | Put options by funds: $1.25M

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

2.28% less ownership

Funds ownership: 99.46% → 97.18% (-2.3%)

5% less funds holding

Funds holding: 170 → 161 (-9)

13% less capital invested

Capital invested by funds: $741M → $647M (-$94.1M)

29% less repeat investments, than reductions

Existing positions increased: 42 | Existing positions reduced: 59

33% less first-time investments, than exits

New positions opened: 16 | Existing positions closed: 24

Holders
161
Holders Change
-9
Holders Change %
-5.29%
% of All Funds
2.16%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
16
Increased
42
Reduced
59
Closed
24
Calls
$3.5M
Puts
$1.25M
Net Calls
+$2.25M
Net Calls Change
-$2.23M

Top Buyers

Rank Fund Capital Flow
1
Nordea Investment Management
Nordea Investment Management
Sweden
+$4.35M
2
SL
Siren LLC
Connecticut
+$2.6M
3
DA
DCF Advisers
Connecticut
+$1.29M
4
Jane Street
Jane Street
New York
+$1.09M
5
Wellington Management Group
Wellington Management Group
Massachusetts
+$971K

Top Sellers

Rank Fund Capital Flow
1
State Street
State Street
Massachusetts
-$4.81M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$3.25M
3
Federated Hermes
Federated Hermes
Pennsylvania
-$2.83M
4
RSCM
Rock Springs Capital Management
Maryland
-$2.15M
5
Vanguard Group
Vanguard Group
Pennsylvania
-$1.9M
Name Holding Trade Value Shares
Change 		Change in
Stake
EWA
126
EverSource Wealth Advisors
Alabama
$3.76K +$2.83K +200 +192%
ACM
127
Aster Capital Management
United Arab Emirates
$3.59K -$863 -61 -21%
SW
128
SVB Wealth
Massachusetts
$3.39K +$3.87K +274 New
MCM
129
Manchester Capital Management
Vermont
$3.09K – – –
CIAM
130
Caitong International Asset Management
Hong Kong
$2.94K +$1.74K +123 +107%
SWM
131
Spire Wealth Management
Virginia
$2.48K +$2.83K +200 New
EPIM
132
Evelyn Partners Investment Management
$2.46K – – –
ADL
133
Asset Dedication LLC
California
$2.28K – – –
Daiwa Securities Group
134
Daiwa Securities Group
Japan
$2K – – –
Osaic Holdings
135
Osaic Holdings
Arizona
$1.99K -$1.39K -98 -38%
NC
136
North Capital
Utah
$1.97K +$2.25K +159 New
SN
137
Sittner & Nelson
Oregon
$1.92K – – –
IA
138
IFP Advisors
Florida
$1.63K – – –
AFG
139
Albion Financial Group
Utah
$1.55K – – –
MPWT
140
MassMutual Private Wealth & Trust
Connecticut
$1.39K +$1.3K +92 +460%
GC
141
Gould Capital
Washington
$1.24K – – –
HIA
142
Harbor Investment Advisory
Maryland
$1.24K – – –
CFO
143
CVA Family Office
Colorado
$891 – – –
PA
144
Parallel Advisors
California
$866 – – –
TC
145
Truvestments Capital
Florida
$842 – – –
CCM
146
Coldstream Capital Management
Washington
$632 +$721 +51 New
RIL
147
Rothschild Investment LLC
Illinois
$557 +$141 +10 +29%
LFG
148
Larson Financial Group
Missouri
$520 +$156 +11 +35%
CIBC Private Wealth Group
149
CIBC Private Wealth Group
Georgia
$514 – – –
AF
150
Allworth Financial
California
$454 +$368 +26 +124%
4 5
6
7 8

PRTA Hedge Fund Activity: Q1 2025 in Review

161 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Prothena Corp (PRTA) for Q1 2025, worth a combined $647M — down 13% from $741M a quarter earlier.

Sellers outnumbered buyers: 24 funds closed out of PRTA and 16 opened new positions — a net loss of 8 holders — while 59 trimmed existing stakes and 42 added.

The largest buyer was Nordea Investment Management, opening a new position worth an estimated $4.35M. The largest seller was State Street, cutting an estimated $4.81M.

  • 161 institutional investors held Prothena Corp (PRTA) as of Q1 2025, down from 170 in Q4 2024.
  • Funds reported $647M of Prothena Corp stock for Q1 2025, down 13% quarter-over-quarter.
  • 16 funds opened new Prothena Corp positions in Q1 2025 and 24 closed out, a net change of -8 holders.
  • The largest Prothena Corp buyer in Q1 2025 was Nordea Investment Management, an estimated $4.35M added.
  • The largest Prothena Corp seller in Q1 2025 was State Street, an estimated $4.81M sold.

Based on aggregated 13F filings for Q1 2025.