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Prothena Corp
PRTA

Overview Fund Activity

187 hedge funds and large institutions have $254M invested in Prothena Corp in 2025 Q2 according to their latest regulatory filings, with 52 funds opening new positions, 54 increasing their positions, 41 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
187
Holders Change
+28
Holders Change %
+17.61%
% of All Funds
2.51%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
52
Increased
54
Reduced
41
Closed
22
Calls
$6.7M
Puts
$6.34M
Net Calls
+$359K
Net Calls Change
-$1.89M

Top Buyers

1
ACM
ADAR1 Capital Management
Texas
$20.5M
2
Citadel Advisors
Citadel Advisors
Florida
$6.97M
3
Acadian Asset Management
Acadian Asset Management
Massachusetts
$6.18M
4
Vanguard Group
Vanguard Group
Pennsylvania
$13.2M
5
RC
Rangeley Capital
Connecticut
$4.34M

Top Sellers

1
EC
EcoR1 Capital
California
$0
2
Wellington Management Group
Wellington Management Group
Massachusetts
$655K
3
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$432K
4
SL
Siren LLC
Connecticut
$0
5
BCM
Boxer Capital Management
California
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
Simplex Trading
76
Simplex Trading
Illinois
$262K +$262K +43,264 New
Man Group
77
Man Group
United Kingdom
$260K +$156K +25,752 +151%
C
78
Covestor
United Kingdom
$257K +$257K +42,291 +1,057,275%
Ohio Public Employees Retirement System (OPERS)
79
Ohio Public Employees Retirement System (OPERS)
Ohio
$256K +$256K +42,158 New
PP
80
PDT Partners
New York
$251K -$662K -109,035 -73%
Wells Fargo
81
Wells Fargo
California
$250K -$28.3K -4,669 -10%
EGM
82
Engineers Gate Manager
New York
$249K +$249K +40,967 New
Deutsche Bank
83
Deutsche Bank
Germany
$240K -$341K -56,209 -59%
Thrivent Financial for Lutherans
84
Thrivent Financial for Lutherans
Minnesota
$234K – – –
SFI
85
Susquehanna Fundamental Investments
Pennsylvania
$228K -$226K -37,181 -50%
Invesco
86
Invesco
Georgia
$224K -$4.57K -753 -2%
GCM
87
Graham Capital Management
Connecticut
$207K +$207K +34,042 New
California State Teachers Retirement System (CalSTRS)
88
California State Teachers Retirement System (CalSTRS)
California
$202K – – –
DFCM
89
Dark Forest Capital Management
Puerto Rico
$199K +$71.7K +11,807 +56%
Group One Trading
90
Group One Trading
Illinois
$196K +$196K +32,258 New
FWM
91
Focused Wealth Management
New York
$195K – – –
RC
92
RBF Capital
California
$177K – – –
AA
93
ALPS Advisors
Colorado
$176K -$54.2K -8,928 -24%
Tudor Investment Corp
94
Tudor Investment Corp
Connecticut
$170K +$170K +27,999 New
Cambridge Investment Research Advisors
95
Cambridge Investment Research Advisors
Iowa
$166K +$104K +17,147 +169%
SPA
96
Sherbrooke Park Advisers
New York
$165K +$165K +27,221 New
MIM
97
MetLife Investment Management
New Jersey
$154K – – –
PCA
98
Purkiss Capital Advisors
Connecticut
$151K +$19.9K +3,275 +15%
Edgewood Management
99
Edgewood Management
Connecticut
$146K – – –
PD
100
Point72 (DIFC)
United Arab Emirates
$145K +$145K +23,946 New
2 3
4
5 6