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Prothena Corp

181 hedge funds and large institutions have $452M invested in Prothena Corp in 2025 Q4 according to their latest regulatory filings, with 25 funds opening new positions, 62 increasing their positions, 57 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

8.64% more ownership

Funds ownership: 79.15%87.78% (+8.6%)

9% more capital invested

Capital invested by funds: $416M → $452M (+$35.8M)

9% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 57

4% less first-time investments, than exits

New positions opened: 25 | Existing positions closed: 26

3% less funds holding

Funds holding: 187181 (-6)

16% less call options, than puts

Call options by funds: $6.74M | Put options by funds: $8.02M

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
181
Holders Change
-6
Holders Change %
-3.21%
% of All Funds
2.2%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
25
Increased
62
Reduced
57
Closed
26
Calls
$6.74M
Puts
$8.02M
Net Calls
-$1.28M
Net Calls Change
+$6.27M
Name Holding Trade Value Shares
Change
Change in
Stake
Russell Investments Group
51
Russell Investments Group
United Kingdom
$949K -$289K -28,407 -22%
CCIA
52
Campbell & Co Investment Adviser
Maryland
$899K +$959K +94,155 New
HWAM
53
Hennion & Walsh Asset Management
New Jersey
$872K +$68.1K +6,686 +8%
ECM
54
ExodusPoint Capital Management
New York
$840K +$588K +57,736 +191%
Rafferty Asset Management
55
Rafferty Asset Management
New York
$788K +$840K +82,553 New
T. Rowe Price Associates
56
T. Rowe Price Associates
Maryland
$779K +$30.2K +2,968 +4%
American Century Companies
57
American Century Companies
Missouri
$753K +$66.8K +6,565 +9%
Assenagon Asset Management
58
Assenagon Asset Management
Luxembourg
$733K -$132K -12,935 -14%
AllianceBernstein
59
AllianceBernstein
Tennessee
$665K
DWAM
60
Duncan Williams Asset Management
Tennessee
$625K -$184K -18,058 -20%
MAM
61
Martingale Asset Management
Massachusetts
$606K +$646K +63,453 New
SG Americas Securities
62
SG Americas Securities
New York
$602K +$64.1K +6,299 +11%
PA
63
Pinnacle Associates
New York
$599K -$86.9K -8,537 -12%
Creative Planning
64
Creative Planning
Kansas
$592K -$22.1K -2,171 -3%
CM
65
Caption Management
Oklahoma
$583K
Wells Fargo
66
Wells Fargo
California
$574K +$200K +19,678 +49%
SPS
67
Susquehanna Portfolio Strategies
Pennsylvania
$562K +$304K +29,878 +103%
RhumbLine Advisers
68
RhumbLine Advisers
Massachusetts
$540K -$56.1K -5,515 -9%
XT
69
XTX Topco
Cayman Islands
$524K +$398K +39,073 +247%
Marshall Wace
70
Marshall Wace
United Kingdom
$523K +$558K +54,778 New
QOP
71
Quinn Opportunity Partners
Virginia
$478K
Franklin Resources
72
Franklin Resources
California
$451K -$142K -13,921 -23%
Massachusetts Financial Services
73
Massachusetts Financial Services
Massachusetts
$439K -$15.5K -1,519 -3%
SFCM
74
Seven Fleet Capital Management
California
$414K +$441K +43,300 New
Ohio Public Employees Retirement System (OPERS)
75
Ohio Public Employees Retirement System (OPERS)
Ohio
$403K