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Prothena Corp

181 hedge funds and large institutions have $452M invested in Prothena Corp in 2025 Q4 according to their latest regulatory filings, with 25 funds opening new positions, 62 increasing their positions, 57 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

8.64% more ownership

Funds ownership: 79.15%87.78% (+8.6%)

9% more capital invested

Capital invested by funds: $416M → $452M (+$35.8M)

9% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 57

4% less first-time investments, than exits

New positions opened: 25 | Existing positions closed: 26

3% less funds holding

Funds holding: 187181 (-6)

16% less call options, than puts

Call options by funds: $6.74M | Put options by funds: $8.02M

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
181
Holders Change
-6
Holders Change %
-3.21%
% of All Funds
2.2%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
25
Increased
62
Reduced
57
Closed
26
Calls
$6.74M
Puts
$8.02M
Net Calls
-$1.28M
Net Calls Change
+$6.27M
Name Holding Trade Value Shares
Change
Change in
Stake
Two Sigma Advisers
26
Two Sigma Advisers
New York
$4.08M +$1.65M +161,700 +61%
Bank of America
27
Bank of America
North Carolina
$4.08M +$1.53M +150,264 +54%
UBS Group
28
UBS Group
Switzerland
$4.07M +$260K +25,513 +6%
BNP Paribas Financial Markets
29
BNP Paribas Financial Markets
France
$4.05M +$1.99M +195,945 +86%
Qube Research & Technologies (QRT)
30
Qube Research & Technologies (QRT)
United Kingdom
$3.89M +$1.56M +153,444 +60%
Northern Trust
31
Northern Trust
Illinois
$3.47M +$291K +28,584 +9%
Charles Schwab
32
Charles Schwab
California
$3.41M +$66.3K +6,514 +2%
Arrowstreet Capital
33
Arrowstreet Capital
Massachusetts
$2.85M -$3.63M -356,193 -54%
Man Group
34
Man Group
United Kingdom
$2.57M +$1.4M +137,540 +104%
MCM
35
Monimus Capital Management
New Jersey
$2.43M -$40K -3,934 -2%
JF
36
Jump Financial
Illinois
$2.27M +$525K +51,581 +28%
Squarepoint
37
Squarepoint
New York
$2.08M +$926K +91,008 +72%
DA
38
DCF Advisers
Connecticut
$1.87M -$50.9K -5,000 -2%
AQR Capital Management
39
AQR Capital Management
Connecticut
$1.78M -$283K -27,757 -13%
Barclays
40
Barclays
United Kingdom
$1.75M +$871K +85,550 +87%
JP Morgan Chase
41
JP Morgan Chase
New York
$1.62M -$5.76M -565,810 -77%
Walleye Capital
42
Walleye Capital
New York
$1.49M +$1.59M +155,972 +247,575%
Bank of New York Mellon
43
Bank of New York Mellon
New York
$1.27M -$215K -21,100 -14%
Connor, Clark & Lunn Investment Management (CC&L)
44
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$1.2M +$1.28M +125,890 New
FWM
45
Focused Wealth Management
New York
$1.03M +$513K +50,350 +88%
DP
46
Diadema Partners
New Jersey
$1.02M +$1.08M +106,539 New
Ameriprise
47
Ameriprise
Minnesota
$1.01M -$967 -95 -0.1%
Los Angeles Capital Management
48
Los Angeles Capital Management
California
$1,000K -$245K -24,018 -20%
QCM
49
Quantinno Capital Management
New York
$990K +$24.7K +2,431 +2%
YIH
50
Y-Intercept (HK)
Hong Kong
$960K +$899K +88,339 +726%