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OptimizeRx
OPRX

110 hedge funds and large institutions have $168M invested in OptimizeRx in 2025 Q2 according to their latest regulatory filings, with 31 funds opening new positions, 32 increasing their positions, 25 reducing their positions, and 7 closing their positions.

New
Increased
Maintained
Reduced
Closed

343% more first-time investments, than exits

New positions opened: 31 | Existing positions closed: 7

147% more call options, than puts

Call options by funds: $3.09M | Put options by funds: $1.25M

65% more capital invested

Capital invested by funds: $102M → $168M (+$66.6M)

28% more repeat investments, than reductions

Existing positions increased: 32 | Existing positions reduced: 25

26% more funds holding

Funds holding: 87 → 110 (+23)

3.89% more ownership

Funds ownership: 63.47% → 67.35% (+3.9%)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

Holders
110
Holders Change
+23
Holders Change %
+26.44%
% of All Funds
1.45%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
31
Increased
32
Reduced
25
Closed
7
Calls
$3.09M
Puts
$1.25M
Net Calls
+$1.84M
Net Calls Change
+$3.44M

Top Buyers

Rank Fund Capital Flow
1
MHP
Manatuck Hill Partners
Connecticut
+$2.9M
2
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$1.71M
3
SSA
Schonfeld Strategic Advisors
New York
+$1.33M
4
Citadel Advisors
Citadel Advisors
Florida
+$1.21M
5
UBS Group
UBS Group
Switzerland
+$990K

Top Sellers

Rank Fund Capital Flow
1
Invesco
Invesco
Georgia
-$2.54M
2
RA
Royce & Associates
New York
-$2.23M
3
Marshall Wace
Marshall Wace
United Kingdom
-$1.52M
4
BlackRock
BlackRock
New York
-$1.09M
5
Janney Montgomery Scott
Janney Montgomery Scott
Pennsylvania
-$1.08M
Name Holding Trade Value Shares
Change 		Change in
Stake
BCM
26
Bridgeway Capital Management
Texas
$1.34M – – –
Bank of New York Mellon
27
Bank of New York Mellon
New York
$1.21M +$2.61K +239 +0.3%
Raymond James Financial
28
Raymond James Financial
Florida
$1.14M +$925K +84,555 New
N
29
Nuveen
North Carolina
$1.09M +$311K +28,410 +54%
Renaissance Technologies
30
Renaissance Technologies
New York
$1.05M +$850K +77,707 New
AC
31
Avenir Corporation
Virginia
$1.04M – – –
Ameriprise
32
Ameriprise
Minnesota
$943K +$764K +69,880 New
EI
33
EAM Investors
California
$859K +$696K +63,596 New
Janus Henderson Group
34
Janus Henderson Group
United Kingdom
$774K +$627K +57,302 New
Charles Schwab
35
Charles Schwab
California
$695K -$29.7K -2,716 -5%
PAWC
36
P.A.W. Capital
Connecticut
$675K +$547K +50,000 New
Goldman Sachs
37
Goldman Sachs
New York
$661K -$22.5K -2,061 -4%
CCIA
38
Campbell & Co Investment Adviser
Maryland
$653K -$2.87K -262 -0.5%
Calamos Advisors
39
Calamos Advisors
Illinois
$623K +$140K +12,774 +38%
AllianceBernstein
40
AllianceBernstein
Tennessee
$538K +$140K +12,800 +47%
PCM
41
Perkins Capital Management
Minnesota
$528K -$49.2K -4,500 -10%
RhumbLine Advisers
42
RhumbLine Advisers
Massachusetts
$487K +$90.8K +8,297 +30%
Bank of America
43
Bank of America
North Carolina
$462K -$31.1K -2,843 -8%
Connor, Clark & Lunn Investment Management (CC&L)
44
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$418K +$339K +30,944 New
Barclays
45
Barclays
United Kingdom
$413K +$93.3K +8,528 +39%
Susquehanna International Group
46
Susquehanna International Group
Pennsylvania
$387K +$6.7K +612 +2%
LPL Financial
47
LPL Financial
California
$356K +$289K +26,390 New
Los Angeles Capital Management
48
Los Angeles Capital Management
California
$349K +$282K +25,823 New
XT
49
XTX Topco
Cayman Islands
$344K +$279K +25,493 New
Walleye Capital
50
Walleye Capital
New York
$339K +$161K +14,677 +141%
1
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OPRX Hedge Fund Activity: Q2 2025 in Review

110 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in OptimizeRx (OPRX) for Q2 2025, worth a combined $168M — up 65% from $102M a quarter earlier.

Buyers outnumbered sellers: 31 funds opened new OPRX positions and 7 closed out — a net gain of 24 holders — while 32 added to existing stakes and 25 trimmed.

The largest buyer was Manatuck Hill Partners, adding an estimated $2.9M. The largest seller was Invesco, exiting entirely with an estimated $2.54M sold.

  • 110 institutional investors held OptimizeRx (OPRX) as of Q2 2025, up from 87 in Q1 2025.
  • Funds reported $168M of OptimizeRx stock for Q2 2025, up 65% quarter-over-quarter.
  • 31 funds opened new OptimizeRx positions in Q2 2025 and 7 closed out, a net change of +24 holders.
  • The largest OptimizeRx buyer in Q2 2025 was Manatuck Hill Partners, an estimated $2.9M added.
  • The largest OptimizeRx seller in Q2 2025 was Invesco, an estimated $2.54M sold.

Based on aggregated 13F filings for Q2 2025.