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MEDP

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$30.5M +$29.8M +1,021,937 New
Adage Capital Partners
2
Adage Capital Partners
Massachusetts
$20.9M +$20.4M +700,000 New
HM
3
HealthCor Management
New York
$9.76M +$9.54M +326,685 New
NCGI
4
Next Century Growth Investors
Minnesota
$9.73M +$9.52M +325,964 New
Massachusetts Financial Services
5
Massachusetts Financial Services
Massachusetts
$9.21M +$9.01M +308,492 New
FA
6
Friess Associates
Delaware
$8.07M +$7.9M +270,380 New
O
7
OppenheimerFunds
New York
$7.64M +$7.47M +255,740 New
CLM
8
ClearBridge LLC (Maryland)
Maryland
$6.19M +$6.06M +207,438 New
BFA
9
BlackRock Fund Advisors
California
$6.06M +$5.92M +202,811 New
Wellington Management Group
10
Wellington Management Group
Massachusetts
$5.86M +$5.73M +196,256 New
BIT
11
BlackRock Institutional Trust
California
$5.12M +$5M +171,296 New
PVI
12
Pura Vida Investments
New York
$4.73M +$4.63M +158,428 New
ACH
13
ArrowMark Colorado Holdings
Colorado
$4.48M +$4.38M +150,058 New
MIM
14
Monashee Investment Management
Massachusetts
$4.48M – – –
RSCM
15
Rock Springs Capital Management
Maryland
$4.03M +$3.94M +135,000 New
Invesco
16
Invesco
Georgia
$3.65M +$3.57M +122,397 New
SCM
17
Sio Capital Management
New York
$3.46M +$3.39M +116,053 New
JP Morgan Chase
18
JP Morgan Chase
New York
$3.11M +$3.04M +104,275 New
Millennium Management
19
Millennium Management
New York
$2.98M +$2.91M +99,770 New
Vanguard Group
20
Vanguard Group
Pennsylvania
$2.84M +$2.78M +95,155 New
State Street
21
State Street
Massachusetts
$2.68M +$2.62M +89,775 New
Federated Hermes
22
Federated Hermes
Pennsylvania
$2.24M +$2.19M +75,000 New
TCM
23
Tygh Capital Management
Oregon
$2.08M +$2.03M +69,560 New
Geode Capital Management
24
Geode Capital Management
Massachusetts
$2.07M +$2.02M +69,219 New
Citadel Advisors
25
Citadel Advisors
Florida
$1.56M +$1.52M +52,162 New
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