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Name Holding Trade Value Shares
Change
Change in
Stake
FCMI
26
Foresite Capital Management IV
California
$10.9M -$17.8M -751,196 -53%
Charles Schwab
27
Charles Schwab
California
$8.93M +$252K +10,622 +2%
Nuveen
28
Nuveen
North Carolina
$8.86M -$751K -31,678 -5%
Axa
29
Axa
France
$8.78M +$8.93M +376,837 +220%
VOYA Investment Management
30
VOYA Investment Management
Georgia
$8.68M +$559K +23,599 +5%
Artisan Partners
31
Artisan Partners
Wisconsin
$8.32M +$12.3M +518,818 New
Morgan Stanley
32
Morgan Stanley
New York
$8.28M -$12.3M -517,569 -50%
PC
33
Polar Capital
United Kingdom
$8.02M +$5.93M +250,000 +100%
CWG
34
C WorldWide Group
Denmark
$7.1M
RHJA
35
Rice Hall James & Associates
California
$7M -$315K -13,303 -3%
Millennium Management
36
Millennium Management
New York
$6.9M -$9.35M -394,419 -48%
American Century Companies
37
American Century Companies
Missouri
$6.89M +$136K +5,749 +1%
Bank of New York Mellon
38
Bank of New York Mellon
New York
$6.49M +$112K +4,744 +1%
GIM
39
Granahan Investment Management
Massachusetts
$6.46M -$4.28M -180,542 -31%
Deutsche Bank
40
Deutsche Bank
Germany
$5.9M -$1.03M -43,360 -11%
CAM
41
Cormorant Asset Management
Massachusetts
$5.81M +$8.59M +362,273 New
Lord, Abbett & Co
42
Lord, Abbett & Co
New Jersey
$5.51M +$3.76M +158,738 +86%
Principal Financial Group
43
Principal Financial Group
Iowa
$5.09M +$2.37M +99,983 +46%
Dimensional Fund Advisors
44
Dimensional Fund Advisors
Texas
$4.36M -$313K -13,190 -5%
FCMI
45
Foresite Capital Management II
California
$3.79M -$15.3M -643,469 -73%
Hudson Bay Capital Management
46
Hudson Bay Capital Management
Connecticut
$3.69M +$3.08M +130,000 +130%
PHS
47
PFM Health Sciences
California
$3.67M +$5.42M +228,781 New
JP Morgan Chase
48
JP Morgan Chase
New York
$3.13M -$3.55M -149,586 -43%
California Public Employees Retirement System
49
California Public Employees Retirement System
California
$2.91M -$2.15M -90,603 -33%
IC
50
Ikarian Capital
Texas
$2.77M +$4.1M +172,919 New