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Name Holding Trade Value Shares
Change
Change in
Stake
BBA
1
Baker Bros. Advisors
New York
$4.3B +$2.56M +20,150 +0.1%
Vanguard Group
2
Vanguard Group
Pennsylvania
$2.16B +$218M +1,709,685 +11%
Wellington Management Group
3
Wellington Management Group
Massachusetts
$1.77B +$31.7M +248,832 +2%
BlackRock
4
BlackRock
New York
$1.7B +$14.7M +115,609 +0.9%
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$1.05B -$113M -890,893 -10%
Sands Capital Management
6
Sands Capital Management
Virginia
$1.01B +$475M +3,733,233 +88%
State Street
7
State Street
Massachusetts
$945M -$9.24M -72,617 -1%
Capital World Investors
8
Capital World Investors
California
$855M -$83.1M -653,350 -9%
Capital International Investors
9
Capital International Investors
California
$807M +$31.3M +246,134 +4%
BB
10
BB Biotech
Switzerland
$443M +$3.18M +25,000 +0.7%
Invesco
11
Invesco
Georgia
$397M -$5.18M -40,671 -1%
Franklin Resources
12
Franklin Resources
California
$381M -$6.2M -48,745 -2%
Fidelity Investments
13
Fidelity Investments
Massachusetts
$289M -$87M -683,734 -23%
Norges Bank
14
Norges Bank
Norway
$265M +$63.3M +497,517 +31%
JP Morgan Chase
15
JP Morgan Chase
New York
$229M +$14.2M +111,252 +7%
MCMC
16
Matrix Capital Management Company
New Hampshire
$226M +$50.5M +396,716 +28%
Northern Trust
17
Northern Trust
Illinois
$225M -$4.56M -35,860 -2%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$224M +$668K +5,250 +0.3%
Bank of New York Mellon
19
Bank of New York Mellon
New York
$223M -$8.21M -64,485 -4%
Goldman Sachs
20
Goldman Sachs
New York
$219M -$34.6M -272,120 -14%
O
21
OrbiMed
New York
$209M -$39.5M -310,197 -16%
UBS AM
22
UBS AM
Illinois
$206M +$20.2M +158,574 +11%
Jennison Associates
23
Jennison Associates
New York
$165M +$74.2M +583,423 +80%
FAM
24
Fred Alger Management
New York
$147M -$32.2M -253,094 -18%
American Century Companies
25
American Century Companies
Missouri
$136M -$6.27M -49,302 -4%