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Monte Rosa Therapeutics

161 hedge funds and large institutions have $1.01B invested in Monte Rosa Therapeutics in 2025 Q4 according to their latest regulatory filings, with 49 funds opening new positions, 54 increasing their positions, 39 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed

206% more first-time investments, than exits

New positions opened: 49 | Existing positions closed: 16

127% more capital invested

Capital invested by funds: $445M → $1.01B (+$566M)

50% more funds holding in top 10

Funds holding in top 10: 23 (+1)

38% more repeat investments, than reductions

Existing positions increased: 54 | Existing positions reduced: 39

25% more funds holding

Funds holding: 129161 (+32)

1.8% more ownership

Funds ownership: 97.22%99.02% (+1.8%)

25% less call options, than puts

Call options by funds: $4.75M | Put options by funds: $6.37M

Holders
161
Holders Change
+32
Holders Change %
+24.81%
% of All Funds
1.96%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
49
Increased
54
Reduced
39
Closed
16
Calls
$4.75M
Puts
$6.37M
Net Calls
-$1.62M
Net Calls Change
+$437K
Name Holding Trade Value Shares
Change
Change in
Stake
CC
51
Casdin Capital
New York
$1.35M
D.E. Shaw & Co
52
D.E. Shaw & Co
New York
$1.34M +$475K +35,275 +70%
Franklin Resources
53
Franklin Resources
California
$1.34M +$563K +41,811 +96%
EI
54
EAM Investors
California
$1.1M +$944K +70,037 New
Canada Pension Plan Investment Board
55
Canada Pension Plan Investment Board
Ontario, Canada
$1.07M +$918K +68,100 New
RC
56
Rangeley Capital
Connecticut
$1.06M -$613K -45,500 -40%
Rafferty Asset Management
57
Rafferty Asset Management
New York
$1.06M +$909K +67,438 New
AllianceBernstein
58
AllianceBernstein
Tennessee
$995K
AR
59
Advisory Research
Illinois
$991K +$852K +63,220 New
DP
60
Diadema Partners
New Jersey
$977K +$839K +62,281 New
RhumbLine Advisers
61
RhumbLine Advisers
Massachusetts
$970K -$28.1K -2,087 -3%
SC
62
Stempoint Capital
New York
$966K +$830K +61,577 New
SEI Investments
63
SEI Investments
Pennsylvania
$936K +$583K +43,262 +264%
NCM
64
Nantahala Capital Management
Connecticut
$909K +$781K +57,991 New
Wells Fargo
65
Wells Fargo
California
$825K +$220K +16,308 +45%
Massachusetts Financial Services
66
Massachusetts Financial Services
Massachusetts
$778K +$669K +49,630 New
Citadel Advisors
67
Citadel Advisors
Florida
$725K -$64K -4,746 -9%
SO
68
STRS Ohio
Ohio
$566K +$486K +36,100 New
Voloridge Investment Management
69
Voloridge Investment Management
Florida
$561K +$482K +35,783 New
Simplex Trading
70
Simplex Trading
Illinois
$551K +$27.1K +2,011 +6%
QCM
71
Quantinno Capital Management
New York
$527K +$46.7K +3,466 +12%
Deutsche Bank
72
Deutsche Bank
Germany
$519K +$115K +8,537 +35%
JGC
73
J. Goldman & Co
New York
$506K +$435K +32,291 New
XT
74
XTX Topco
Cayman Islands
$488K -$256K -19,003 -38%
ACM
75
Aquatic Capital Management
Illinois
$485K +$417K +30,940 New