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ERAS

Name Holding Trade Value Shares
Change 		Change in
Stake
FLSM
1
Frazier Life Sciences Management
California
$399M +$23M +1,945,752 +9%
T. Rowe Price Investment Management
2
T. Rowe Price Investment Management
Maryland
$344M +$60.8M +5,148,232 +32%
BlackRock
3
BlackRock
New York
$326M +$53.8M +4,554,076 +29%
VA
4
VR Adviser
New York
$265M -$17.4M -1,474,271 -8%
RI
5
RTW Investments
New York
$261M +$189M +16,010,524 +10,917%
VC
6
Vivo Capital
California
$197M +$34M +2,878,052 +31%
Vanguard Capital Management
7
Vanguard Capital Management
Pennsylvania
$182M +$133M +11,249,738 New
SL
8
Siren LLC
Connecticut
$182M +$29.4M +2,486,997 +28%
LGM
9
Logos Global Management
California
$180M -$21.9M -1,850,000 -14%
PBA
10
Paradigm Biocapital Advisors
New York
$168M -$44.5M -3,766,393 -27%
State Street
11
State Street
Massachusetts
$150M +$36.9M +3,125,442 +51%
AVM
12
Arch Venture Management
Illinois
$115M -$46.9M -3,963,997 -36%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$97M +$12.6M +1,069,814 +22%
CAM
14
Cormorant Asset Management
Massachusetts
$93.8M +$68.6M +5,800,000 New
AAA
15
Affinity Asset Advisors
New York
$86.6M +$17.1M +1,450,000 +37%
Balyasny Asset Management
16
Balyasny Asset Management
Illinois
$83.2M +$59.6M +5,045,912 +5,145%
Goldman Sachs
17
Goldman Sachs
New York
$78.9M +$18.2M +1,543,768 +46%
Janus Henderson Group
18
Janus Henderson Group
$60M +$43.9M +3,710,966 New
5VM
19
5AM Venture Management
California
$56.4M -$22.7M -1,919,433 -36%
SCM
20
Suvretta Capital Management
New York
$55.6M -$131M -11,067,037 -76%
CC
21
Commodore Capital
New York
$51.4M +$37.5M +3,175,000 New
Bank of America
22
Bank of America
North Carolina
$49.4M +$17.1M +1,444,047 +90%
ACM
23
AH Capital Management
California
$46.3M – – –
WP
24
Woodline Partners
California
$45.8M +$10.6M +900,896 +47%
Adage Capital Partners
25
Adage Capital Partners
Massachusetts
$34M +$24.8M +2,100,000 New
1
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