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154 hedge funds and large institutions have $816M invested in Erasca in 2025 Q4 according to their latest regulatory filings, with 32 funds opening new positions, 44 increasing their positions, 47 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

4,833% more call options, than puts

Call options by funds: $10.9M | Put options by funds: $221K

78% more first-time investments, than exits

New positions opened: 32 | Existing positions closed: 18

74% more capital invested

Capital invested by funds: $469M → $816M (+$347M)

67% more funds holding in top 10

Funds holding in top 10: 35 (+2)

9% more funds holding

Funds holding: 141154 (+13)

1.53% more ownership

Funds ownership: 75.76%77.29% (+1.5%)

6% less repeat investments, than reductions

Existing positions increased: 44 | Existing positions reduced: 47

Holders
154
Holders Change
+13
Holders Change %
+9.22%
% of All Funds
1.87%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.06%
New
32
Increased
44
Reduced
47
Closed
18
Calls
$10.9M
Puts
$221K
Net Calls
+$10.7M
Net Calls Change
+$10.1M
Name Holding Trade Value Shares
Change
Change in
Stake
Northern Trust
26
Northern Trust
Illinois
$4.95M -$315K -112,003 -8%
SCM
27
Silverarc Capital Management
Massachusetts
$4.9M -$142K -50,491 -4%
JP Morgan Chase
28
JP Morgan Chase
New York
$4.29M -$326K -115,952 -9%
Citadel Advisors
29
Citadel Advisors
Florida
$3.83M +$1.94M +688,546 +201%
RSCM
30
Rock Springs Capital Management
Maryland
$3.54M +$2.68M +951,710 New
Jane Street
31
Jane Street
New York
$3.39M +$1.48M +526,450 +136%
TCM
32
Tang Capital Management
California
$3.35M -$1.7M -602,915 -40%
Renaissance Technologies
33
Renaissance Technologies
New York
$3.16M -$464K -164,905 -16%
Morgan Stanley
34
Morgan Stanley
New York
$3.01M +$1.52M +541,715 +202%
IC
35
Ikarian Capital
Texas
$2.74M +$2.07M +735,396 New
AQR Capital Management
36
AQR Capital Management
Connecticut
$2.49M +$15.6K +5,537 +0.8%
Bank of New York Mellon
37
Bank of New York Mellon
New York
$2.03M -$76.4K -27,159 -5%
Wellington Management Group
38
Wellington Management Group
Massachusetts
$2.02M -$161K -57,384 -10%
HF
39
HRT Financial
New York
$2M +$1.51M +536,909 New
Fidelity Investments
40
Fidelity Investments
Massachusetts
$1.94M +$287K +101,901 +24%
N
41
Nuveen
North Carolina
$1.58M -$71.3K -25,343 -6%
Barclays
42
Barclays
United Kingdom
$1.5M +$378K +134,544 +50%
Creative Planning
43
Creative Planning
Kansas
$1.42M +$88.3K +31,381 +9%
Simplex Trading
44
Simplex Trading
Illinois
$1.29M +$660K +234,735 +211%
Invesco
45
Invesco
Georgia
$1.23M +$134K +47,770 +17%
Squarepoint
46
Squarepoint
New York
$961K +$488K +173,574 +205%
DCM
47
DAFNA Capital Management
California
$947K -$269K -95,564 -27%
TD Asset Management
48
TD Asset Management
Ontario, Canada
$855K -$73.7K -26,192 -10%
Wells Fargo
49
Wells Fargo
California
$819K +$173K +61,531 +39%
AllianceBernstein
50
AllianceBernstein
Tennessee
$777K -$69.2K -24,620 -11%

ERAS Hedge Fund Activity: Q4 2025 in Review

154 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Erasca (ERAS) for Q4 2025, worth a combined $816M — up 74% from $469M a quarter earlier.

Buyers outnumbered sellers: 32 funds opened new ERAS positions and 18 closed out — a net gain of 14 holders — while 44 added to existing stakes and 47 trimmed.

The largest buyer was State Street, adding an estimated $6.03M. The largest seller was T. Rowe Price Investment Management, cutting an estimated $11.6M.

  • 154 institutional investors held Erasca (ERAS) as of Q4 2025, up from 141 in Q3 2025.
  • Funds reported $816M of Erasca stock for Q4 2025, up 74% quarter-over-quarter.
  • 32 funds opened new Erasca positions in Q4 2025 and 18 closed out, a net change of +14 holders.
  • The largest Erasca buyer in Q4 2025 was State Street, an estimated $6.03M added.
  • The largest Erasca seller in Q4 2025 was T. Rowe Price Investment Management, an estimated $11.6M sold.

Based on aggregated 13F filings for Q4 2025.