enGene Therapeutics
ENGN
58 hedge funds and large institutions have $531M invested in enGene Therapeutics in 2025 Q4 according to their latest regulatory filings, with 27 funds opening new positions, 17 increasing their positions, 8 reducing their positions, and 6 closing their positions.
350% more first-time investments, than exits
New positions opened: 27 | Existing positions closed: 6
113% more repeat investments, than reductions
Existing positions increased: 17 | Existing positions reduced: 8
90% more capital invested
Capital invested by funds: $279M → $531M (+$252M)
57% more funds holding
Funds holding: 37 → 58 (+21)
33% more funds holding in top 10
Funds holding in top 10: 3 → 4 (+1)
7.95% more ownership
Funds ownership: 79.81% → 87.77% (+8%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
PA
Perceptive Advisors
New York
|
+$30.2M |
| 2 |
SL
Siren LLC
Greenwich,
Connecticut
|
+$26.7M |
| 3 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
+$17.1M |
| 4 |
NI
Nextech Invest
Zurich,
Switzerland
|
+$17M |
| 5 |
Janus Henderson Group
London,
|
+$15.2M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
KCM
Kynam Capital Management
Princeton,
New Jersey
|
-$28.1M |
| 2 |
FLSM
Frazier Life Sciences Management
Palo Alto,
California
|
-$7.9M |
| 3 |
Adage Capital Partners
Boston,
Massachusetts
|
-$6.83M |
| 4 |
Point72 Asset Management
Stamford,
Connecticut
|
-$5.18M |
| 5 |
Bank of America
Charlotte,
North Carolina
|
-$4.42M |
ENGN Hedge Fund Activity: Q4 2025 in Review
58 of the 8,270 institutional investors tracked by Wall St. Rank reported a position in enGene Therapeutics (ENGN) for Q4 2025, worth a combined $531M — up 90% from $279M a quarter earlier.
Buyers outnumbered sellers: 27 funds opened new ENGN positions and 6 closed out — a net gain of 21 holders — while 17 added to existing stakes and 8 trimmed.
The largest buyer was Perceptive Advisors, adding an estimated $30.2M. The largest seller was Kynam Capital Management, cutting an estimated $28.1M.
- 58 institutional investors held enGene Therapeutics (ENGN) as of Q4 2025, up from 37 in Q3 2025.
- Funds reported $531M of enGene Therapeutics stock for Q4 2025, up 90% quarter-over-quarter.
- 27 funds opened new enGene Therapeutics positions in Q4 2025 and 6 closed out, a net change of +21 holders.
- The largest enGene Therapeutics buyer in Q4 2025 was Perceptive Advisors, an estimated $30.2M added.
- The largest enGene Therapeutics seller in Q4 2025 was Kynam Capital Management, an estimated $28.1M sold.
Based on aggregated 13F filings for Q4 2025.