|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$46.5M
|
+$18.3M
|
+1,754,834
|
+53%
|
|
|
2
|
BVF Inc
San Francisco,
California
|
$45.9M
|
+$82K
|
+7,853
|
+0.2%
|
|
|
3
|
Lansdowne Partners (UK)
London,
United Kingdom
|
$21.3M
|
–
|
–
|
–
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$16.5M
|
-$76K
|
-7,276
|
-0.4%
|
|
|
5
|
Wasatch Advisors
Salt Lake City,
Utah
|
$15.8M
|
-$239K
|
-22,936
|
-1%
|
|
|
6
|
Wellington Management Group
Boston,
Massachusetts
|
$14.7M
|
-$2.1M
|
-201,341
|
-11%
|
|
|
7
|
BlackRock Institutional Trust
San Francisco,
California
|
$9.99M
|
-$224K
|
-21,454
|
-2%
|
|
|
8
|
State Street
Boston,
Massachusetts
|
$8.94M
|
+$3.65M
|
+349,954
|
+56%
|
|
|
9
|
BlackRock Fund Advisors
San Francisco,
California
|
$8.57M
|
+$543K
|
+52,043
|
+6%
|
|
|
10
|
EcoR1 Capital
San Francisco,
California
|
$7.77M
|
-$13.5M
|
-1,293,043
|
-60%
|
|
|
11
|
|
$6.5M
|
-$39.5K
|
-3,781
|
-0.5%
|
|
|
12
|
Northern Trust
Chicago,
Illinois
|
$3.27M
|
+$549K
|
+52,561
|
+17%
|
|
|
13
|
Millennium Management
New York
|
$2.87M
|
+$3.26M
|
+312,200
|
New
|
|
|
14
|
|
$2.85M
|
+$65.6K
|
+6,279
|
+2%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$2.51M
|
+$19K
|
+1,817
|
+0.7%
|
|
|
16
|
Freedom Investment Management
Hartford,
Connecticut
|
$1.78M
|
-$56.6K
|
-5,423
|
-3%
|
|
|
17
|
DAFNA Capital Management
Los Angeles,
California
|
$1.67M
|
+$331K
|
+31,737
|
+21%
|
|
|
18
|
PNC Financial Services Group
Pittsburgh,
Pennsylvania
|
$1.6M
|
-$498K
|
-47,728
|
-22%
|
|
|
19
|
Bank of New York Mellon
New York
|
$1.47M
|
-$47.6K
|
-4,560
|
-3%
|
|
|
20
|
United Services Automobile Association
San Antonio,
Texas
|
$1.46M
|
-$3.97K
|
-380
|
-0.2%
|
|
|
21
|
BlackRock Investment Management
Wilmington,
Delaware
|
$1.24M
|
+$56.8K
|
+5,440
|
+4%
|
|
|
22
|
Ironwood Investment Management
Boston,
Massachusetts
|
$1.23M
|
-$184K
|
-17,597
|
-12%
|
|
|
23
|
|
$1.22M
|
+$319K
|
+30,523
|
+30%
|
|
|
24
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$1.2M
|
+$702K
|
+67,201
|
+106%
|
|
|
25
|
Palo Alto Investors
Palo Alto,
California
|
$1.14M
|
–
|
–
|
–
|
|
