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Cytokinetics

311 hedge funds and large institutions have $4.55B invested in Cytokinetics in 2025 Q2 according to their latest regulatory filings, with 28 funds opening new positions, 143 increasing their positions, 104 reducing their positions, and 71 closing their positions.

New
Increased
Maintained
Reduced
Closed

371% more call options, than puts

Call options by funds: $216M | Put options by funds: $45.9M

38% more repeat investments, than reductions

Existing positions increased: 143 | Existing positions reduced: 104

0.19% more ownership

Funds ownership: 115.09%115.28% (+0.19%)

0% more funds holding in top 10

Funds holding in top 10: 1212 (0)

12% less funds holding

Funds holding: 355311 (-44)

18% less capital invested

Capital invested by funds: $5.58B → $4.55B (-$1.03B)

61% less first-time investments, than exits

New positions opened: 28 | Existing positions closed: 71

Holders
311
Holders Change
-44
Holders Change %
-12.39%
% of All Funds
4.09%
Holding in Top 10
12
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.16%
New
28
Increased
143
Reduced
104
Closed
71
Calls
$216M
Puts
$45.9M
Net Calls
+$170M
Net Calls Change
+$32.6M
Name Holding Trade Value Shares
Change
Change in
Stake
RhumbLine Advisers
51
RhumbLine Advisers
Massachusetts
$12.9M +$559K +16,085 +4%
AQR Capital Management
52
AQR Capital Management
Connecticut
$11.5M +$11.4M +327,745 +1,639%
Ameriprise
53
Ameriprise
Minnesota
$11.4M -$15.4M -441,617 -56%
Group One Trading
54
Group One Trading
Illinois
$11M +$4.48M +128,770 +63%
SFM
55
Sphera Funds Management
Israel
$10.8M +$6.32M +181,757 +125%
Schroder Investment Management Group
56
Schroder Investment Management Group
United Kingdom
$10.3M -$1.21M -34,707 -10%
N
57
Nuveen
North Carolina
$10.2M -$1.53M -43,869 -12%
PCM
58
Pentwater Capital Management
Florida
$9.91M +$2.78M +80,000 +36%
BNP Paribas Financial Markets
59
BNP Paribas Financial Markets
France
$9.59M +$1.83M +52,647 +22%
SPS
60
Susquehanna Portfolio Strategies
Pennsylvania
$8.73M +$9.19M +264,329 New
EAM
61
Eventide Asset Management
Massachusetts
$8.24M -$4.63M -133,196 -35%
IC
62
Ikarian Capital
Texas
$7.71M +$2.9M +83,482 +56%
Swiss National Bank
63
Swiss National Bank
Switzerland
$7.14M -$34.8K -1,000 -0.5%
WP
64
Woodline Partners
California
$7.01M
PA
65
Pinnacle Associates
New York
$6.89M -$2.15M -61,908 -23%
Ensign Peak Advisors
66
Ensign Peak Advisors
Utah
$6.74M +$5.99M +172,150 +541%
QOP
67
Quinn Opportunity Partners
Virginia
$6.44M +$2.26M +65,000 +50%
GGHC
68
Gilder Gagnon Howe & Co
New York
$6.31M +$6.13M +176,253 +1,186%
Legal & General Group
69
Legal & General Group
United Kingdom
$6M +$134K +3,856 +2%
Manulife (Manufacturers Life Insurance)
70
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$5.79M +$264K +7,595 +5%
Impax Asset Management Group
71
Impax Asset Management Group
United Kingdom
$5.78M
Rafferty Asset Management
72
Rafferty Asset Management
New York
$5.67M +$768K +22,074 +15%
PCM
73
Peregrine Capital Management
Minnesota
$5.24M +$97.1K +2,791 +2%
Hudson Bay Capital Management
74
Hudson Bay Capital Management
Connecticut
$5.21M +$366K +10,523 +7%
Capital Fund Management (CFM)
75
Capital Fund Management (CFM)
France
$5.1M +$3.45M +99,117 +179%

CYTK Hedge Fund Activity: Q2 2025 in Review

311 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Cytokinetics (CYTK) for Q2 2025, worth a combined $4.55B — down 18% from $5.58B a quarter earlier.

Sellers outnumbered buyers: 71 funds closed out of CYTK and 28 opened new positions — a net loss of 43 holders — while 104 trimmed existing stakes and 143 added.

The largest buyer was T. Rowe Price Investment Management, adding an estimated $266M. The largest seller was Marshall Wace, cutting an estimated $69.8M.

  • 311 institutional investors held Cytokinetics (CYTK) as of Q2 2025, down from 355 in Q1 2025.
  • Funds reported $4.55B of Cytokinetics stock for Q2 2025, down 18% quarter-over-quarter.
  • 28 funds opened new Cytokinetics positions in Q2 2025 and 71 closed out, a net change of -43 holders.
  • The largest Cytokinetics buyer in Q2 2025 was T. Rowe Price Investment Management, an estimated $266M added.
  • The largest Cytokinetics seller in Q2 2025 was Marshall Wace, an estimated $69.8M sold.

Based on aggregated 13F filings for Q2 2025.