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Cue Biopharma

47 hedge funds and large institutions have $6.66M invested in Cue Biopharma in 2025 Q4 according to their latest regulatory filings, with 7 funds opening new positions, 8 increasing their positions, 10 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed

0.14% more ownership

Funds ownership: 0.78%0.92% (+0.14%)

8% less funds holding

Funds holding: 5147 (-4)

20% less repeat investments, than reductions

Existing positions increased: 8 | Existing positions reduced: 10

36% less first-time investments, than exits

New positions opened: 7 | Existing positions closed: 11

49% less capital invested

Capital invested by funds: $13M → $6.66M (-$6.32M)

Holders
47
Holders Change
-4
Holders Change %
-7.84%
% of All Funds
0.57%
Holding in Top 10
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
7
Increased
8
Reduced
10
Closed
11
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
BL
1
Bleichroeder LP
New York
$2.08M
GWMR
2
GC Wealth Management RIA
Massachusetts
$1.41M +$735K +40,000 +35%
Vanguard Group
3
Vanguard Group
Pennsylvania
$919K -$15.5K -843 -0.8%
LPC
4
Lion Point Capital
New York
$673K +$1.35M +73,428 New
Geode Capital Management
5
Geode Capital Management
Massachusetts
$245K +$1.54K +84 +0.3%
BFM
6
Boothbay Fund Management
New York
$215K +$57.2K +3,112 +15%
RSWM
7
Robertson Stephens Wealth Management
California
$146K
BlackRock
8
BlackRock
New York
$137K
TCBWMS
9
Texas Capital Bank Wealth Management Services
Texas
$135K +$250K +13,586 +1,232%
AWM
10
Angeles Wealth Management
California
$94.7K +$116K +6,333 +158%
AR
11
Advisory Research
Illinois
$78.6K
Stifel Financial
12
Stifel Financial
Missouri
$75.3K +$30.6K +1,667 +25%
Renaissance Technologies
13
Renaissance Technologies
New York
$72.8K +$6.91K +376 +5%
Bank of America
14
Bank of America
North Carolina
$63.3K -$71.6K -3,898 -36%
State Street
15
State Street
Massachusetts
$54.8K -$6.38K -347 -5%
Susquehanna International Group
16
Susquehanna International Group
Pennsylvania
$51.6K +$1.45K +79 +1%
CPIG
17
Chicago Partners Investment Group
Illinois
$32.7K
Northern Trust
18
Northern Trust
Illinois
$30.8K
Northwestern Mutual Wealth Management
19
Northwestern Mutual Wealth Management
Wisconsin
$24.3K
Jane Street
20
Jane Street
New York
$21.3K +$42.7K +2,326 New
UBS Group
21
UBS Group
Switzerland
$14.3K -$93.3K -5,077 -76%
LPL Financial
22
LPL Financial
California
$14.2K
SPC
23
Sigma Planning Corp
Michigan
$12.5K -$7.51K -409 -23%
NA
24
NewEdge Advisors
Louisiana
$6.11K
Cambridge Investment Research Advisors
25
Cambridge Investment Research Advisors
Iowa
$6K

CUE Hedge Fund Activity: Q4 2025 in Review

47 of the 8,228 institutional investors tracked by Wall St. Rank reported a position in Cue Biopharma (CUE) for Q4 2025, worth a combined $6.66M — down 49% from $13M a quarter earlier.

Sellers outnumbered buyers: 11 funds closed out of CUE and 7 opened new positions — a net loss of 4 holders — while 10 trimmed existing stakes and 8 added.

The largest buyer was Lion Point Capital, opening a new position worth an estimated $1.35M. The largest seller was UBS Group, cutting an estimated $93.3K.

  • 47 institutional investors held Cue Biopharma (CUE) as of Q4 2025, down from 51 in Q3 2025.
  • Funds reported $6.66M of Cue Biopharma stock for Q4 2025, down 49% quarter-over-quarter.
  • 7 funds opened new Cue Biopharma positions in Q4 2025 and 11 closed out, a net change of -4 holders.
  • The largest Cue Biopharma buyer in Q4 2025 was Lion Point Capital, an estimated $1.35M added.
  • The largest Cue Biopharma seller in Q4 2025 was UBS Group, an estimated $93.3K sold.

Based on aggregated 13F filings for Q4 2025.