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Castle Biosciences

180 hedge funds and large institutions have $516M invested in Castle Biosciences in 2025 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 77 increasing their positions, 54 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more call options, than puts

Call options by funds: $200K | Put options by funds: $112K

43% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 54

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

3.89% less ownership

Funds ownership: 94.63%90.74% (-3.9%)

9% less funds holding

Funds holding: 197180 (-17)

27% less capital invested

Capital invested by funds: $706M → $516M (-$190M)

34% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 44

Holders
180
Holders Change
-17
Holders Change %
-8.63%
% of All Funds
2.41%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
29
Increased
77
Reduced
54
Closed
44
Calls
$200K
Puts
$112K
Net Calls
+$88K
Net Calls Change
-$2.62M
Name Holding Trade Value Shares
Change
Change in
Stake
Group One Trading
201
Group One Trading
Illinois
-$243K -9,796 Closed
Manulife (Manufacturers Life Insurance)
202
Manulife (Manufacturers Life Insurance)
Ontario, Canada
-$252K -9,467 Closed
GAA
203
Green Alpha Advisors
Colorado
-$249K -9,327 Closed
CL
204
Choreo LLC
Illinois
-$244K -9,155 Closed
PTC
205
Petrus Trust Company
Texas
-$244K -9,151 Closed
Janus Henderson Group
206
Janus Henderson Group
United Kingdom
-$243K -9,137 Closed
Cambridge Investment Research Advisors
207
Cambridge Investment Research Advisors
Iowa
-$243K -9,102 Closed
ProShare Advisors
208
ProShare Advisors
Maryland
-$230K -8,613 Closed
VOYA Investment Management
209
VOYA Investment Management
Georgia
-$210K -7,876 Closed
ASRS
210
Arizona State Retirement System
Arizona
-$203K -7,599 Closed
CFGS
211
Concourse Financial Group Securities
Alabama
-$185K -6,960 Closed
RA
212
RiverPark Advisors
New York
-$84.5K -3,170 Closed
CAS
213
Coppell Advisory Solutions
Texas
-$51.3K -1,924 Closed
RS
214
R Squared
Hong Kong
-$42.4K -1,590 Closed
MA
215
MCF Advisors
Kentucky
-$6.88K -258 Closed
NA
216
NewEdge Advisors
Louisiana
-$6.58K -247 Closed
Comerica Bank
217
Comerica Bank
Texas
-$5.52K -207 Closed
IA
218
IFP Advisors
Florida
-$4.29K -161 Closed
Federated Hermes
219
Federated Hermes
Pennsylvania
-$3.04K -114 Closed
CIBC Private Wealth Group
220
CIBC Private Wealth Group
Georgia
-$1.7K -52 Closed
AAP
221
Arax Advisory Partners
Colorado
-$827 -31 Closed
LFG
222
Larson Financial Group
Missouri
-$320 -12 Closed
ACM
223
Aster Capital Management
United Arab Emirates
-$240 -9 Closed
AWM
224
Avior Wealth Management
Nebraska
-$26 -1 Closed

CSTL Hedge Fund Activity: Q1 2025 in Review

180 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q1 2025, worth a combined $516M — down 27% from $706M a quarter earlier.

Sellers outnumbered buyers: 44 funds closed out of CSTL and 29 opened new positions — a net loss of 15 holders — while 54 trimmed existing stakes and 77 added.

The largest buyer was Schroder Investment Management Group, opening a new position worth an estimated $14.8M. The largest seller was Wasatch Advisors, cutting an estimated $19.7M.

  • 180 institutional investors held Castle Biosciences (CSTL) as of Q1 2025, down from 197 in Q4 2024.
  • Funds reported $516M of Castle Biosciences stock for Q1 2025, down 27% quarter-over-quarter.
  • 29 funds opened new Castle Biosciences positions in Q1 2025 and 44 closed out, a net change of -15 holders.
  • The largest Castle Biosciences buyer in Q1 2025 was Schroder Investment Management Group, an estimated $14.8M added.
  • The largest Castle Biosciences seller in Q1 2025 was Wasatch Advisors, an estimated $19.7M sold.

Based on aggregated 13F filings for Q1 2025.