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Castle Biosciences

180 hedge funds and large institutions have $516M invested in Castle Biosciences in 2025 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 77 increasing their positions, 54 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more call options, than puts

Call options by funds: $200K | Put options by funds: $112K

43% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 54

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

3.89% less ownership

Funds ownership: 94.63%90.74% (-3.9%)

9% less funds holding

Funds holding: 197180 (-17)

27% less capital invested

Capital invested by funds: $706M → $516M (-$190M)

34% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 44

Holders
180
Holders Change
-17
Holders Change %
-8.63%
% of All Funds
2.41%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
29
Increased
77
Reduced
54
Closed
44
Calls
$200K
Puts
$112K
Net Calls
+$88K
Net Calls Change
-$2.62M
Name Holding Trade Value Shares
Change
Change in
Stake
RIL
176
Rothschild Investment LLC
Illinois
$400 -$495 -20 -50%
MTIC
177
Missouri Trust & Investment Company
Missouri
$380
BIG
178
Brooklyn Investment Group
New York
$221 +$272 +11 New
FFA
179
Farther Finance Advisors
California
$99
HNB
180
Huntington National Bank
Ohio
$20
SCM
181
Soleus Capital Management
Connecticut
-$6.74M -252,917 Closed
NCGI
182
Next Century Growth Investors
Minnesota
-$6.27M -235,214 Closed
IECM
183
Intrinsic Edge Capital Management
Illinois
-$6.2M -232,711 Closed
CAPTRUST Financial Advisors
184
CAPTRUST Financial Advisors
North Carolina
-$5.74M -215,322 Closed
GIM
185
Granahan Investment Management
Massachusetts
-$2.95M -110,824 Closed
Ohio Public Employees Retirement System (OPERS)
186
Ohio Public Employees Retirement System (OPERS)
Ohio
-$1.98M -74,132 Closed
LCG
187
Lisanti Capital Growth
New York
-$1.23M -46,265 Closed
Arrowstreet Capital
188
Arrowstreet Capital
Massachusetts
-$770K -28,903 Closed
LPL Financial
189
LPL Financial
California
-$614K -23,043 Closed
HA
190
Huntleigh Advisors
Missouri
-$591K -22,167 Closed
YIH
191
Y-Intercept (HK)
Hong Kong
-$582K -21,839 Closed
ACM
192
Aquatic Capital Management
Illinois
-$539K -20,218 Closed
N
193
Natixis
France
-$522K -19,600 Closed
ADIM
194
Alpha DNA Investment Management
Maryland
-$404K -15,174 Closed
CMF
195
Counterpoint Mutual Funds
California
-$362K -13,587 Closed
CAM
196
Cresset Asset Management
Illinois
-$331K -12,405 Closed
JF
197
Jump Financial
Illinois
-$304K -11,400 Closed
FRM
198
Fox Run Management
Connecticut
-$286K -10,716 Closed
LCM
199
Legato Capital Management
California
-$277K -10,395 Closed
B
200
Bailard
California
-$264K -9,900 Closed

CSTL Hedge Fund Activity: Q1 2025 in Review

180 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q1 2025, worth a combined $516M — down 27% from $706M a quarter earlier.

Sellers outnumbered buyers: 44 funds closed out of CSTL and 29 opened new positions — a net loss of 15 holders — while 54 trimmed existing stakes and 77 added.

The largest buyer was Schroder Investment Management Group, opening a new position worth an estimated $14.8M. The largest seller was Wasatch Advisors, cutting an estimated $19.7M.

  • 180 institutional investors held Castle Biosciences (CSTL) as of Q1 2025, down from 197 in Q4 2024.
  • Funds reported $516M of Castle Biosciences stock for Q1 2025, down 27% quarter-over-quarter.
  • 29 funds opened new Castle Biosciences positions in Q1 2025 and 44 closed out, a net change of -15 holders.
  • The largest Castle Biosciences buyer in Q1 2025 was Schroder Investment Management Group, an estimated $14.8M added.
  • The largest Castle Biosciences seller in Q1 2025 was Wasatch Advisors, an estimated $19.7M sold.

Based on aggregated 13F filings for Q1 2025.