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Castle Biosciences
CSTL

194 hedge funds and large institutions have $1.06B invested in Castle Biosciences in 2025 Q4 according to their latest regulatory filings, with 43 funds opening new positions, 64 increasing their positions, 68 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

139% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 18

100% more funds holding in top 10

Funds holding in top 10: 1 → 2 (+1)

75% more capital invested

Capital invested by funds: $608M → $1.06B (+$453M)

12% more funds holding

Funds holding: 173 → 194 (+21)

1.66% more ownership

Funds ownership: 91.87% → 93.52% (+1.7%)

6% less repeat investments, than reductions

Existing positions increased: 64 | Existing positions reduced: 68

Holders
194
Holders Change
+21
Holders Change %
+12.14%
% of All Funds
2.36%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.02%
New
43
Increased
64
Reduced
68
Closed
18
Calls
$3.25M
Puts
–
Net Calls
+$3.25M
Net Calls Change
+$2.48M

Top Buyers

1
RI
RTW Investments
New York
+$68.2M
2
SPPAM
Summit Partners Public Asset Management
Massachusetts
+$21.2M
3
EAM
Eventide Asset Management
Massachusetts
+$9.83M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$7.05M
5
PCM
Portolan Capital Management
Massachusetts
+$6.91M

Top Sellers

1
B
Braidwell
Connecticut
-$20.8M
2
N
Nuveen
North Carolina
-$13.9M
3
Dimensional Fund Advisors
Dimensional Fund Advisors
Texas
-$10.6M
4
PHP
Parkman Healthcare Partners
Connecticut
-$10.5M
5
Millennium Management
Millennium Management
New York
-$8.58M
Name Holding Trade Value Shares
Change 		Change in
Stake
SO
101
STRS Ohio
Ohio
$490K +$90.3K +2,800 +29%
SGI
102
Summit Global Investments
Utah
$481K +$419 +13 +0.1%
II
103
Inspire Investing
Idaho
$467K -$254K -7,876 -40%
DWM
104
Diversify Wealth Management
Utah
$459K -$5.13K -159 -1%
IIM
105
INTECH Investment Management
Florida
$456K -$21.7K -674 -5%
Man Group
106
Man Group
United Kingdom
$451K +$373K +11,585 New
JCIA
107
Jackson Creek Investment Advisors
Colorado
$437K +$362K +11,235 New
SI
108
Stephens Inc
Arkansas
$433K – – –
GCM
109
Graham Capital Management
Connecticut
$425K -$329K -10,205 -48%
LPL Financial
110
LPL Financial
California
$423K +$47.7K +1,480 +16%
TP
111
TritonPoint Partners
Maryland
$419K +$347K +10,777 New
ACM
112
Aquatic Capital Management
Illinois
$411K +$265K +8,235 +353%
GAA
113
Green Alpha Advisors
Colorado
$398K +$22.5K +698 +7%
QCM
114
Quantinno Capital Management
New York
$363K +$301K +9,332 New
Cetera Investment Advisers
115
Cetera Investment Advisers
Illinois
$348K +$288K +8,935 New
SQA
116
Simon Quick Advisors
New Jersey
$333K -$161K -5,001 -37%
Manulife (Manufacturers Life Insurance)
117
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$330K -$33.9K -1,052 -11%
GT
118
Glenmede Trust
Pennsylvania
$319K +$264K +8,190 New
ASRS
119
Arizona State Retirement System
Arizona
$314K +$260K +8,071 New
PFSRSONJ
120
Police & Firemen's Retirement System of New Jersey
New Jersey
$305K – – –
IB
121
Intrust Bank
Kansas
$287K +$238K +7,378 New
State Board of Administration of Florida Retirement System
122
State Board of Administration of Florida Retirement System
Florida
$278K +$231K +7,154 New
VA
123
Verdad Advisers
Massachusetts
$276K +$228K +7,085 New
Arrowstreet Capital
124
Arrowstreet Capital
Massachusetts
$273K +$227K +7,029 New
Commonwealth Equity Services
125
Commonwealth Equity Services
Massachusetts
$256K +$212K +6,591 New
3 4
5
6 7

CSTL Hedge Fund Activity: Q4 2025 in Review

194 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q4 2025, worth a combined $1.06B — up 75% from $608M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new CSTL positions and 18 closed out — a net gain of 25 holders — while 64 added to existing stakes and 68 trimmed.

The largest buyer was RTW Investments, opening a new position worth an estimated $68.2M. The largest seller was Braidwell, cutting an estimated $20.8M.

  • 194 institutional investors held Castle Biosciences (CSTL) as of Q4 2025, up from 173 in Q3 2025.
  • Funds reported $1.06B of Castle Biosciences stock for Q4 2025, up 75% quarter-over-quarter.
  • 43 funds opened new Castle Biosciences positions in Q4 2025 and 18 closed out, a net change of +25 holders.
  • The largest Castle Biosciences buyer in Q4 2025 was RTW Investments, an estimated $68.2M added.
  • The largest Castle Biosciences seller in Q4 2025 was Braidwell, an estimated $20.8M sold.

Based on aggregated 13F filings for Q4 2025.