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Castle Biosciences

180 hedge funds and large institutions have $516M invested in Castle Biosciences in 2025 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 77 increasing their positions, 54 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more call options, than puts

Call options by funds: $200K | Put options by funds: $112K

43% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 54

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

3.89% less ownership

Funds ownership: 94.63%90.74% (-3.9%)

9% less funds holding

Funds holding: 197180 (-17)

27% less capital invested

Capital invested by funds: $706M → $516M (-$190M)

34% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 44

Holders
180
Holders Change
-17
Holders Change %
-8.63%
% of All Funds
2.41%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
29
Increased
77
Reduced
54
Closed
44
Calls
$200K
Puts
$112K
Net Calls
+$88K
Net Calls Change
-$2.62M
Name Holding Trade Value Shares
Change
Change in
Stake
SPA
101
Sherbrooke Park Advisers
New York
$389K +$175K +7,067 +57%
Russell Investments Group
102
Russell Investments Group
United Kingdom
$373K +$284K +11,457 +159%
SO
103
STRS Ohio
Ohio
$366K
II
104
Inspire Investing
Idaho
$343K -$708K -28,597 -63%
OHIS
105
Oak Harvest Investment Services
Texas
$338K +$227K +9,156 +118%
CC
106
Centiva Capital
New York
$336K -$154K -6,213 -27%
HCA
107
Harbor Capital Advisors
Illinois
$332K -$2.52M -101,905 -86%
CAU
108
Caxton Associates (UK)
$329K +$407K +16,440 New
Wells Fargo
109
Wells Fargo
California
$327K +$24.1K +972 +6%
IIM
110
INTECH Investment Management
Florida
$322K +$111K +4,500 +39%
MIM
111
MetLife Investment Management
New Jersey
$315K -$7.13K -288 -2%
Mirae Asset Global ETFs Holdings
112
Mirae Asset Global ETFs Holdings
Hong Kong
$309K +$16.2K +655 +4%
QT
113
Quantbot Technologies
New York
$306K +$378K +15,287 New
FBT
114
First Bank & Trust
South Dakota
$303K +$161K +6,512 +76%
Man Group
115
Man Group
United Kingdom
$291K +$30K +1,212 +9%
SI
116
Stephens Inc
Arkansas
$273K -$19.8K -800 -6%
SQA
117
Simon Quick Advisors
New Jersey
$272K +$495 +20 +0.1%
M1FG
118
Mach-1 Financial Group
Arkansas
$267K +$330K +13,313 New
DWM
119
Diversify Wealth Management
Utah
$260K +$17.8K +717 +6%
WG
120
Winton Group
United Kingdom
$258K +$319K +12,869 New
CF
121
Corebridge Financial
Texas
$258K +$149 +6 +0%
BHCM
122
Brevan Howard Capital Management
Jersey
$244K +$302K +12,205 New
Zurich Cantonal Bank
123
Zurich Cantonal Bank
Switzerland
$242K -$38.6K -1,561 -11%
Universal-Beteiligungs- und Servicegesellschaft
124
Universal-Beteiligungs- und Servicegesellschaft
Germany
$235K +$291K +11,753 New
MF
125
Magnetar Financial
Illinois
$225K +$278K +11,226 New

CSTL Hedge Fund Activity: Q1 2025 in Review

180 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q1 2025, worth a combined $516M — down 27% from $706M a quarter earlier.

Sellers outnumbered buyers: 44 funds closed out of CSTL and 29 opened new positions — a net loss of 15 holders — while 54 trimmed existing stakes and 77 added.

The largest buyer was Schroder Investment Management Group, opening a new position worth an estimated $14.8M. The largest seller was Wasatch Advisors, cutting an estimated $19.7M.

  • 180 institutional investors held Castle Biosciences (CSTL) as of Q1 2025, down from 197 in Q4 2024.
  • Funds reported $516M of Castle Biosciences stock for Q1 2025, down 27% quarter-over-quarter.
  • 29 funds opened new Castle Biosciences positions in Q1 2025 and 44 closed out, a net change of -15 holders.
  • The largest Castle Biosciences buyer in Q1 2025 was Schroder Investment Management Group, an estimated $14.8M added.
  • The largest Castle Biosciences seller in Q1 2025 was Wasatch Advisors, an estimated $19.7M sold.

Based on aggregated 13F filings for Q1 2025.