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Castle Biosciences
CSTL

194 hedge funds and large institutions have $1.06B invested in Castle Biosciences in 2025 Q4 according to their latest regulatory filings, with 43 funds opening new positions, 64 increasing their positions, 68 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

139% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 18

100% more funds holding in top 10

Funds holding in top 10: 1 → 2 (+1)

75% more capital invested

Capital invested by funds: $608M → $1.06B (+$453M)

12% more funds holding

Funds holding: 173 → 194 (+21)

1.66% more ownership

Funds ownership: 91.87% → 93.52% (+1.7%)

6% less repeat investments, than reductions

Existing positions increased: 64 | Existing positions reduced: 68

Holders
194
Holders Change
+21
Holders Change %
+12.14%
% of All Funds
2.36%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.02%
New
43
Increased
64
Reduced
68
Closed
18
Calls
$3.25M
Puts
–
Net Calls
+$3.25M
Net Calls Change
+$2.48M

Top Buyers

1
RI
RTW Investments
New York
+$68.2M
2
SPPAM
Summit Partners Public Asset Management
Massachusetts
+$21.2M
3
EAM
Eventide Asset Management
Massachusetts
+$9.83M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$7.05M
5
PCM
Portolan Capital Management
Massachusetts
+$6.91M

Top Sellers

1
B
Braidwell
Connecticut
-$20.8M
2
N
Nuveen
North Carolina
-$13.9M
3
Dimensional Fund Advisors
Dimensional Fund Advisors
Texas
-$10.6M
4
PHP
Parkman Healthcare Partners
Connecticut
-$10.5M
5
Millennium Management
Millennium Management
New York
-$8.58M
Name Holding Trade Value Shares
Change 		Change in
Stake
AllianceBernstein
76
AllianceBernstein
Tennessee
$983K -$261K -8,100 -24%
Truist Financial
77
Truist Financial
North Carolina
$919K +$8.29K +257 +1%
EGM
78
Engineers Gate Manager
New York
$893K -$759K -23,557 -51%
CAU
79
Caxton Associates (UK)
$874K +$724K +22,464 New
Deutsche Bank
80
Deutsche Bank
Germany
$871K +$185K +5,742 +35%
XT
81
XTX Topco
Cayman Islands
$861K +$713K +22,125 New
FRM
82
Fox Run Management
Connecticut
$851K +$260K +8,064 +58%
SSA
83
Schonfeld Strategic Advisors
New York
$835K -$2.13M -66,215 -76%
SG Americas Securities
84
SG Americas Securities
New York
$827K +$264K +8,201 +63%
HSBC Holdings
85
HSBC Holdings
United Kingdom
$760K -$443K -13,747 -41%
AG
86
Algert Global
California
$738K -$1.25M -38,917 -67%
SC
87
SummitTX Capital
Texas
$677K -$889K -27,590 -61%
A
88
AlphaQuest
New York
$666K +$82.9K +2,572 +18%
Verition Fund Management
89
Verition Fund Management
Connecticut
$654K +$37.7K +1,169 +7%
FBT
90
First Bank & Trust
South Dakota
$650K -$99.7K -3,093 -16%
Creative Planning
91
Creative Planning
Kansas
$628K -$4.35K -135 -0.8%
MIM
92
MetLife Investment Management
New Jersey
$618K – – –
Janus Henderson Group
93
Janus Henderson Group
United Kingdom
$585K +$190K +5,900 +65%
Los Angeles Capital Management
94
Los Angeles Capital Management
California
$572K -$15.8K -490 -2%
PA
95
Parallel Advisors
California
$544K -$123K -3,800 -21%
OHIS
96
Oak Harvest Investment Services
Texas
$525K -$110K -3,398 -20%
HCA
97
Harbor Capital Advisors
Illinois
$523K +$8.41K +261 +2%
YIH
98
Y-Intercept (HK)
Hong Kong
$515K +$427K +13,246 New
Mirae Asset Global ETFs Holdings
99
Mirae Asset Global ETFs Holdings
Hong Kong
$514K -$1.61K -50 -0.4%
CMF
100
Counterpoint Mutual Funds
California
$504K +$418K +12,952 New
2 3
4
5 6

CSTL Hedge Fund Activity: Q4 2025 in Review

194 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q4 2025, worth a combined $1.06B — up 75% from $608M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new CSTL positions and 18 closed out — a net gain of 25 holders — while 64 added to existing stakes and 68 trimmed.

The largest buyer was RTW Investments, opening a new position worth an estimated $68.2M. The largest seller was Braidwell, cutting an estimated $20.8M.

  • 194 institutional investors held Castle Biosciences (CSTL) as of Q4 2025, up from 173 in Q3 2025.
  • Funds reported $1.06B of Castle Biosciences stock for Q4 2025, up 75% quarter-over-quarter.
  • 43 funds opened new Castle Biosciences positions in Q4 2025 and 18 closed out, a net change of +25 holders.
  • The largest Castle Biosciences buyer in Q4 2025 was RTW Investments, an estimated $68.2M added.
  • The largest Castle Biosciences seller in Q4 2025 was Braidwell, an estimated $20.8M sold.

Based on aggregated 13F filings for Q4 2025.