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Castle Biosciences

180 hedge funds and large institutions have $516M invested in Castle Biosciences in 2025 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 77 increasing their positions, 54 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more call options, than puts

Call options by funds: $200K | Put options by funds: $112K

43% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 54

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

3.89% less ownership

Funds ownership: 94.63%90.74% (-3.9%)

9% less funds holding

Funds holding: 197180 (-17)

27% less capital invested

Capital invested by funds: $706M → $516M (-$190M)

34% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 44

Holders
180
Holders Change
-17
Holders Change %
-8.63%
% of All Funds
2.41%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
29
Increased
77
Reduced
54
Closed
44
Calls
$200K
Puts
$112K
Net Calls
+$88K
Net Calls Change
-$2.62M
Name Holding Trade Value Shares
Change
Change in
Stake
American Century Companies
51
American Century Companies
Missouri
$1.48M +$121K +4,892 +7%
SEI Investments
52
SEI Investments
Pennsylvania
$1.46M +$782K +31,568 +76%
Envestnet Asset Management
53
Envestnet Asset Management
Illinois
$1.4M -$88.5K -3,573 -5%
Two Sigma Advisers
54
Two Sigma Advisers
New York
$1.39M +$1.43M +57,700 +502%
GCM
55
Graham Capital Management
Connecticut
$1.37M +$661K +26,709 +64%
UBS AM
56
UBS AM
Illinois
$1.36M +$49.8K +2,013 +3%
GCP
57
GSA Capital Partners
United Kingdom
$1.34M -$90.6K -3,658 -5%
Deutsche Bank
58
Deutsche Bank
Germany
$1.31M -$52.7K -2,130 -3%
Citigroup
59
Citigroup
New York
$1.26M +$529K +21,374 +52%
SSA
60
Schonfeld Strategic Advisors
New York
$1.19M +$1.1M +44,371 +290%
JCIA
61
Jackson Creek Investment Advisors
Colorado
$1.14M +$1.41M +57,094 New
Swiss National Bank
62
Swiss National Bank
Switzerland
$1.09M +$74.3K +3,000 +6%
EGM
63
Engineers Gate Manager
New York
$1.06M +$847K +34,201 +183%
DFCM
64
Dark Forest Capital Management
Puerto Rico
$1.04M +$1.28M +51,855 New
UBS Group
65
UBS Group
Switzerland
$976K -$18.9M -763,841 -94%
CCIA
66
Campbell & Co Investment Adviser
Maryland
$918K -$11.7K -471 -1%
BNP Paribas Financial Markets
67
BNP Paribas Financial Markets
France
$906K -$5.05M -203,898 -82%
Barclays
68
Barclays
United Kingdom
$857K -$153K -6,198 -13%
TW
69
TritonPoint Wealth
Maryland
$834K -$124K -5,000 -11%
RhumbLine Advisers
70
RhumbLine Advisers
Massachusetts
$784K -$17.5K -706 -2%
NRD
71
Nebula Research & Development
New York
$753K +$271K +10,943 +41%
AICPI
72
ABG Innovation Capital Partners III
Hong Kong
$736K
Susquehanna International Group
73
Susquehanna International Group
Pennsylvania
$719K +$457K +18,467 +106%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
74
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$717K
Los Angeles Capital Management
75
Los Angeles Capital Management
California
$680K +$841K +33,970 New

CSTL Hedge Fund Activity: Q1 2025 in Review

180 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q1 2025, worth a combined $516M — down 27% from $706M a quarter earlier.

Sellers outnumbered buyers: 44 funds closed out of CSTL and 29 opened new positions — a net loss of 15 holders — while 54 trimmed existing stakes and 77 added.

The largest buyer was Schroder Investment Management Group, opening a new position worth an estimated $14.8M. The largest seller was Wasatch Advisors, cutting an estimated $19.7M.

  • 180 institutional investors held Castle Biosciences (CSTL) as of Q1 2025, down from 197 in Q4 2024.
  • Funds reported $516M of Castle Biosciences stock for Q1 2025, down 27% quarter-over-quarter.
  • 29 funds opened new Castle Biosciences positions in Q1 2025 and 44 closed out, a net change of -15 holders.
  • The largest Castle Biosciences buyer in Q1 2025 was Schroder Investment Management Group, an estimated $14.8M added.
  • The largest Castle Biosciences seller in Q1 2025 was Wasatch Advisors, an estimated $19.7M sold.

Based on aggregated 13F filings for Q1 2025.