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Caribou Biosciences
CRBU

129 hedge funds and large institutions have $51.9M invested in Caribou Biosciences in 2025 Q2 according to their latest regulatory filings, with 34 funds opening new positions, 28 increasing their positions, 42 reducing their positions, and 36 closing their positions.

New
Increased
Maintained
Reduced
Closed

49% more call options, than puts

Call options by funds: $170K | Put options by funds: $114K

12% more capital invested

Capital invested by funds: $46.5M → $51.9M (+$5.47M)

6% less first-time investments, than exits

New positions opened: 34 | Existing positions closed: 36

2% less funds holding

Funds holding: 131 → 129 (-2)

10.21% less ownership

Funds ownership: 54.03% → 43.83% (-10%)

33% less repeat investments, than reductions

Existing positions increased: 28 | Existing positions reduced: 42

50% less funds holding in top 10

Funds holding in top 10: 2 → 1 (-1)

Holders
129
Holders Change
-2
Holders Change %
-1.53%
% of All Funds
1.7%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
34
Increased
28
Reduced
42
Closed
36
Calls
$170K
Puts
$114K
Net Calls
+$56K
Net Calls Change
+$20K

Top Buyers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
+$718K
2
Royal Bank of Canada
Royal Bank of Canada
Ontario, Canada
+$565K
3
Renaissance Technologies
Renaissance Technologies
New York
+$523K
4
Aberdeen Group
Aberdeen Group
United Kingdom
+$478K
5
P
&Partners
Tennessee
+$331K

Top Sellers

Rank Fund Capital Flow
1
BlackRock
BlackRock
New York
-$4.39M
2
State Street
State Street
Massachusetts
-$1.26M
3
PHS
PFM Health Sciences
California
-$1.13M
4
Geode Capital Management
Geode Capital Management
Massachusetts
-$1.06M
5
JP Morgan Chase
JP Morgan Chase
New York
-$791K
Name Holding Trade Value Shares
Change 		Change in
Stake
7IH
26
72 Investment Holdings
Connecticut
$597K – – –
GAA
27
Green Alpha Advisors
Colorado
$536K -$6.54K -6,646 -2%
MAM
28
Milestone Asset Management
Pennsylvania
$516K +$79.1K +80,472 +24%
State Street
29
State Street
Massachusetts
$451K -$1.26M -1,283,018 -78%
P
30
&Partners
Tennessee
$424K +$331K +336,565 New
Morgan Stanley
31
Morgan Stanley
New York
$418K -$149K -151,283 -31%
Envestnet Asset Management
32
Envestnet Asset Management
Illinois
$402K +$270K +274,812 +627%
Ameriprise
33
Ameriprise
Minnesota
$389K -$97.5K -99,103 -24%
CSS
34
Cubist Systematic Strategies
Connecticut
$388K +$303K +308,001 New
Point72 Asset Management
35
Point72 Asset Management
Connecticut
$365K +$59.9K +60,854 +27%
Thrivent Financial for Lutherans
36
Thrivent Financial for Lutherans
Minnesota
$346K – – –
Susquehanna International Group
37
Susquehanna International Group
Pennsylvania
$333K +$61.4K +62,386 +31%
BC
38
Bruce & Co
Illinois
$315K – – –
UBS Group
39
UBS Group
Switzerland
$314K -$328K -333,775 -57%
Citadel Advisors
40
Citadel Advisors
Florida
$303K +$236K +240,219 New
Northern Trust
41
Northern Trust
Illinois
$267K -$443K -450,055 -68%
GCP
42
GSA Capital Partners
United Kingdom
$210K +$146K +148,791 +845%
BHCM
43
Brevan Howard Capital Management
Jersey
$196K +$153K +155,521 New
BCM
44
Bridgeway Capital Management
Texas
$187K +$39.3K +40,000 +37%
YIH
45
Y-Intercept (HK)
Hong Kong
$173K +$135K +137,211 New
Ohio Public Employees Retirement System (OPERS)
46
Ohio Public Employees Retirement System (OPERS)
Ohio
$162K -$39.5K -40,200 -24%
WP
47
Woodline Partners
California
$155K +$686 +698 +0.6%
HSBC Holdings
48
HSBC Holdings
United Kingdom
$147K +$65.6K +66,670 +139%
HF
49
HRT Financial
New York
$133K +$104K +105,865 New
SL
50
Siren LLC
Connecticut
$133K – – –
1
2
3 4 5

CRBU Hedge Fund Activity: Q2 2025 in Review

129 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Caribou Biosciences (CRBU) for Q2 2025, worth a combined $51.9M — up 12% from $46.5M a quarter earlier.

Sellers outnumbered buyers: 36 funds closed out of CRBU and 34 opened new positions — a net loss of 2 holders — while 42 trimmed existing stakes and 28 added.

The largest buyer was Millennium Management, adding an estimated $718K. The largest seller was BlackRock, cutting an estimated $4.39M.

  • 129 institutional investors held Caribou Biosciences (CRBU) as of Q2 2025, down from 131 in Q1 2025.
  • Funds reported $51.9M of Caribou Biosciences stock for Q2 2025, up 12% quarter-over-quarter.
  • 34 funds opened new Caribou Biosciences positions in Q2 2025 and 36 closed out, a net change of -2 holders.
  • The largest Caribou Biosciences buyer in Q2 2025 was Millennium Management, an estimated $718K added.
  • The largest Caribou Biosciences seller in Q2 2025 was BlackRock, an estimated $4.39M sold.

Based on aggregated 13F filings for Q2 2025.