Cogent Biosciences
COGT
About: Cogent Biosciences Inc a biotechnology company focused on developing precision therapies for genetically defined diseases. It designs rational precision therapies that treat the underlying cause of disease and improve the lives of patients. Its program CGT9486, is a selective tyrosine kinase inhibitor designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. In the vast majority of cases, KIT D816V is responsible for driving Systemic Mastocytosis (SM), a serious disease caused by the unchecked proliferation of mast cells. Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with dependence on oncogenic KIT signaling.
Employees: 205
Fund manager confidence
Based on 2025 Q2 regulatory disclosures by fund managers ($100M+ AUM)
214% more call options, than puts
Call options by funds: $20.5M | Put options by funds: $6.52M
111% more repeat investments, than reductions
Existing positions increased: 78 | Existing positions reduced: 37
22% more capital invested
Capital invested by funds: $800M [Q1] → $973M (+$174M) [Q2]
13% more funds holding in top 10
Funds holding in top 10: 8 [Q1] → 9 (+1) [Q2]
1.78% more ownership
Funds ownership: 117.25% [Q1] → 119.04% (+1.78%) [Q2]
3% less funds holding
Funds holding: 185 [Q1] → 179 (-6) [Q2]
15% less first-time investments, than exits
New positions opened: 29 | Existing positions closed: 34
Research analyst outlook
9 Wall Street Analysts provided 1 year price targets over the past 3 months
9 analyst ratings
Raymond James
Chris Raymond
|
$30
|
Strong Buy
Initiated
|
3 Sep 2025 |
Guggenheim
Charles Zhou
|
$20
|
Buy
Maintained
|
25 Aug 2025 |
JP Morgan
Anupam Rama
|
$30
|
Overweight
Maintained
|
7 Aug 2025 |
HC Wainwright & Co.
Robert Burns
|
$21
|
Buy
Maintained
|
6 Aug 2025 |
Citigroup
David Lebowitz
|
$22
|
Buy
Maintained
|
18 Jul 2025 |
Guggenheim
Michael Schmidt
|
$17
|
Buy
Reiterated
|
8 Jul 2025 |
Baird
Joel Beatty
|
$9
|
Neutral
Maintained
|
8 Jul 2025 |
Leerink Partners
Andrew Berens
|
$18
|
Outperform
Maintained
|
7 Jul 2025 |
Jefferies
Kelly Shi
|
$28
|
Buy
Maintained
|
7 Jul 2025 |
Financial journalist opinion