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CLYM

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CLYM

Name Holding Trade Value Shares
Change 		Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$147M – – –
Fidelity Investments
2
Fidelity Investments
Massachusetts
$88.5M +$70.1M +6,783,967 +106,049%
UBS Group
3
UBS Group
Switzerland
$44.4M +$34.3M +3,318,921 +3,862%
B
4
Braidwell
Connecticut
$36.5M +$13.1M +1,267,700 +83%
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$32.7M +$25.9M +2,506,000 New
BlackRock
6
BlackRock
New York
$30.7M +$20.2M +1,953,223 +486%
T. Rowe Price Associates
7
T. Rowe Price Associates
Maryland
$27.7M +$2.17M +210,313 +11%
CAM
8
Cormorant Asset Management
Massachusetts
$27.5M +$21.8M +2,106,000 New
FCM
9
Frontier Capital Management
Massachusetts
$25.3M +$20M +1,939,019 New
Vanguard Capital Management
10
Vanguard Capital Management
Pennsylvania
$22.2M +$5.37M +519,995 +44%
WP
11
Woodline Partners
California
$20.6M +$16.3M +1,582,291 New
Citadel Advisors
12
Citadel Advisors
Florida
$16.9M +$9.84M +952,309 +276%
RG
13
Redmile Group
California
$16M +$12.7M +1,226,330 New
GPP
14
Great Point Partners
Connecticut
$13M -$3.45M -334,130 -25%
AAA
15
Affinity Asset Advisors
New York
$12.7M +$2.81M +272,000 +39%
Millennium Management
16
Millennium Management
New York
$11.8M -$3.8M -368,062 -29%
ACM
17
ADAR1 Capital Management
Texas
$10.7M +$2.32M +224,987 +38%
DCM
18
Driehaus Capital Management
Illinois
$10.3M +$1.95M +189,054 +31%
Geode Capital Management
19
Geode Capital Management
Massachusetts
$10.2M +$4.85M +469,200 +150%
SC
20
Stempoint Capital
New York
$9.69M +$7.67M +742,745 New
State Street
21
State Street
Massachusetts
$8.96M +$5.73M +554,772 +420%
Ameriprise
22
Ameriprise
Minnesota
$8.58M +$6.8M +657,971 New
PHP
23
Parkman Healthcare Partners
Connecticut
$7.35M +$5.82M +563,484 New
SCM
24
Superstring Capital Management
New York
$6.79M +$3.32M +321,873 +162%
SFM
25
Sphera Funds Management
Israel
$6.31M +$666K +64,500 +15%
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