|
1
|
Sofinnova Investments
Menlo Park,
California
|
–
|
-$74.6M
|
-6,073,949
|
Closed
|
|
|
2
|
5AM Venture Management
San Francisco,
California
|
–
|
-$60.7M
|
-4,937,646
|
Closed
|
|
|
3
|
General Atlantic
New York
|
–
|
-$51.7M
|
-4,209,470
|
Closed
|
|
|
4
|
Perceptive Advisors
New York
|
–
|
-$31.7M
|
-2,576,325
|
Closed
|
|
|
5
|
Adage Capital Partners
Boston,
Massachusetts
|
–
|
-$24.5M
|
-1,994,583
|
Closed
|
|
|
6
|
|
–
|
-$23.4M
|
-1,906,000
|
Closed
|
|
|
7
|
|
–
|
-$21.9M
|
-1,783,419
|
Closed
|
|
|
8
|
T. Rowe Price Associates
Baltimore,
Maryland
|
–
|
-$17.5M
|
-1,423,124
|
Closed
|
|
|
9
|
|
–
|
-$17.1M
|
-1,389,705
|
Closed
|
|
|
10
|
Rock Springs Capital Management
Baltimore,
Maryland
|
–
|
-$13.7M
|
-1,116,578
|
Closed
|
|
|
11
|
Vanguard Group
Malvern,
Pennsylvania
|
–
|
-$13.1M
|
-1,064,718
|
Closed
|
|
|
12
|
Great Point Partners
Greenwich,
Connecticut
|
–
|
-$12.5M
|
-1,019,153
|
Closed
|
|
|
13
|
Baker Bros. Advisors
New York
|
–
|
-$9.9M
|
-807,212
|
Closed
|
|
|
14
|
Omega Fund Management
Boston,
Massachusetts
|
–
|
-$7.85M
|
-560,985
|
Closed
|
|
|
15
|
Sphera Funds Management
Tel Aviv,
Israel
|
–
|
-$6.51M
|
-529,640
|
Closed
|
|
|
16
|
State Street
Boston,
Massachusetts
|
–
|
-$5.62M
|
-457,674
|
Closed
|
|
|
17
|
Vivo Capital
Palo Alto,
California
|
–
|
-$5.18M
|
-421,635
|
Closed
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
–
|
-$5.16M
|
-420,310
|
Closed
|
|
|
19
|
Silverarc Capital Management
Boston,
Massachusetts
|
–
|
-$4.86M
|
-395,382
|
Closed
|
|
|
20
|
venBio Partners
San Francisco,
California
|
–
|
-$4.71M
|
-383,390
|
Closed
|
|
|
21
|
Driehaus Capital Management
Chicago,
Illinois
|
–
|
-$4.36M
|
-354,729
|
Closed
|
|
|
22
|
Schonfeld Strategic Advisors
New York
|
–
|
-$3.08M
|
-250,556
|
Closed
|
|
|
23
|
Millennium Management
New York
|
–
|
-$2.81M
|
-228,773
|
Closed
|
|
|
24
|
Northern Trust
Chicago,
Illinois
|
–
|
-$2.49M
|
-202,372
|
Closed
|
|
|
25
|
|
–
|
-$2.44M
|
-198,946
|
Closed
|
|
