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AstraZeneca
AZN

1,287 hedge funds and large institutions have $37.9B invested in AstraZeneca in 2025 Q3 according to their latest regulatory filings, with 159 funds opening new positions, 546 increasing their positions, 359 reducing their positions, and 76 closing their positions.

New
Increased
Maintained
Reduced
Closed

109% more first-time investments, than exits

New positions opened: 159 | Existing positions closed: 76

91% more funds holding in top 10

Funds holding in top 10: 11 → 21 (+10)

84% more call options, than puts

Call options by funds: $559M | Put options by funds: $303M

52% more repeat investments, than reductions

Existing positions increased: 546 | Existing positions reduced: 359

9% more capital invested

Capital invested by funds: $34.7B → $37.9B (+$3.21B)

5% more funds holding

Funds holding: 1,222 → 1,287 (+65)

0.04% less ownership

Funds ownership: 8% → 7.96% (-0.04%)

Holders
1,287
Holders Change
+65
Holders Change %
+5.32%
% of All Funds
16.89%
Holding in Top 10
21
Holding in Top 10 Change
+10
Holding in Top 10 Change %
+90.91%
% of All Funds
0.28%
New
159
Increased
546
Reduced
359
Closed
76
Calls
$559M
Puts
$303M
Net Calls
+$256M
Net Calls Change
-$80.8M

Top Buyers

Rank Fund Capital Flow
1
Citigroup
Citigroup
New York
+$219M
2
Bank of Montreal
Bank of Montreal
Ontario, Canada
+$204M
3
Holocene Advisors
Holocene Advisors
New York
+$137M
4
Citadel Advisors
Citadel Advisors
Florida
+$133M
5
Goldman Sachs
Goldman Sachs
New York
+$126M

Top Sellers

Rank Fund Capital Flow
1
Jennison Associates
Jennison Associates
New York
-$642M
2
Capital International Investors
Capital International Investors
California
-$481M
3
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$213M
4
Wellington Management Group
Wellington Management Group
Massachusetts
-$154M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$127M
Name Holding Trade Value Shares
Change 		Change in
Stake
Envestnet Asset Management
26
Envestnet Asset Management
Illinois
$295M +$22.2M +146,557 +8%
Citigroup
27
Citigroup
New York
$293M +$219M +1,449,436 +314%
Jennison Associates
28
Jennison Associates
New York
$283M -$642M -4,240,851 -70%
Citadel Advisors
29
Citadel Advisors
Florida
$275M +$133M +877,671 +96%
Bank of Montreal
30
Bank of Montreal
Ontario, Canada
$267M +$204M +1,347,896 +345%
Royal Bank of Canada
31
Royal Bank of Canada
Ontario, Canada
$260M -$4.89M -32,282 -2%
Wells Fargo
32
Wells Fargo
California
$251M +$3.49M +23,083 +1%
WCM Investment Management
33
WCM Investment Management
California
$197M +$808K +5,339 +0.4%
UBS Group
34
UBS Group
Switzerland
$191M +$8.19M +54,140 +5%
Millennium Management
35
Millennium Management
New York
$171M +$81.9M +541,445 +95%
American Century Companies
36
American Century Companies
Missouri
$168M +$47.4M +313,362 +40%
Acadian Asset Management
37
Acadian Asset Management
Massachusetts
$163M +$6.47M +42,746 +4%
Natixis Advisors
38
Natixis Advisors
Massachusetts
$161M +$19.9M +131,232 +14%
VOYA Investment Management
39
VOYA Investment Management
Georgia
$146M +$58.3M +385,208 +68%
MNA
40
Manning & Napier Advisors
New York
$135M -$29.5M -195,171 -18%
SC
41
Saturna Capital
Washington
$125M +$96.9K +640 +0.1%
BNP Paribas Financial Markets
42
BNP Paribas Financial Markets
France
$124M +$80.5M +532,103 +191%
CIC
43
Crawford Investment Counsel
Georgia
$120M +$2.06M +13,607 +2%
AllianceBernstein
44
AllianceBernstein
Tennessee
$107M -$51.8M -342,136 -33%
LP
45
LMR Partners
United Kingdom
$103M +$99.4M +657,001 +5,739%
Lazard Asset Management
46
Lazard Asset Management
New York
$102M +$15.7M +103,825 +18%
Janus Henderson Group
47
Janus Henderson Group
United Kingdom
$99.7M -$93.2M -615,962 -49%
CCMG
48
Clark Capital Management Group
Pennsylvania
$99.3M +$47.5M +313,985 +94%
Parnassus Investments
49
Parnassus Investments
California
$99.2M +$456K +3,012 +0.5%
Stifel Financial
50
Stifel Financial
Missouri
$90.3M +$2.19M +14,455 +3%
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AZN Hedge Fund Activity: Q3 2025 in Review

1,287 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in AstraZeneca (AZN) for Q3 2025, worth a combined $37.9B — up 9.2% from $34.7B a quarter earlier.

Buyers outnumbered sellers: 159 funds opened new AZN positions and 76 closed out — a net gain of 83 holders — while 546 added to existing stakes and 359 trimmed.

The largest buyer was Citigroup, adding an estimated $219M. The largest seller was Jennison Associates, cutting an estimated $642M.

  • 1,287 institutional investors held AstraZeneca (AZN) as of Q3 2025, up from 1,222 in Q2 2025.
  • Funds reported $37.9B of AstraZeneca stock for Q3 2025, up 9.2% quarter-over-quarter.
  • 159 funds opened new AstraZeneca positions in Q3 2025 and 76 closed out, a net change of +83 holders.
  • The largest AstraZeneca buyer in Q3 2025 was Citigroup, an estimated $219M added.
  • The largest AstraZeneca seller in Q3 2025 was Jennison Associates, an estimated $642M sold.

Based on aggregated 13F filings for Q3 2025.