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AstraZeneca
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Overview Fund Activity

1,203 hedge funds and large institutions have $34.6B invested in AstraZeneca in 2025 Q2 according to their latest regulatory filings, with 99 funds opening new positions, 457 increasing their positions, 430 reducing their positions, and 108 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
1,203
Holders Change
-31
Holders Change %
-2.51%
% of All Funds
16.12%
Holding in Top 10
11
Holding in Top 10 Change
-10
Holding in Top 10 Change %
-47.62%
% of All Funds
0.15%
New
99
Increased
457
Reduced
430
Closed
108
Calls
$596M
Puts
$259M
Net Calls
+$337M
Net Calls Change
-$224M

Top Buyers

1
Fayez Sarofim & Co
Fayez Sarofim & Co
Texas
+$166M
2
Acadian Asset Management
Acadian Asset Management
Massachusetts
+$137M
3
Jennison Associates
Jennison Associates
New York
+$112M
4
Raymond James Financial
Raymond James Financial
Florida
+$104M
5
OTPPB
Ontario Teachers' Pension Plan Board
Ontario, Canada
+$96.9M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$359M
2
Morgan Stanley
Morgan Stanley
New York
-$248M
3
SFM
Soros Fund Management
New York
-$202M
4
Arrowstreet Capital
Arrowstreet Capital
Massachusetts
-$170M
5
Fidelity Investments
Fidelity Investments
Massachusetts
-$122M
Name Holding Trade Value Shares
Change 		Shares
Change %
Fayez Sarofim & Co
26
Fayez Sarofim & Co
Texas
$262M +$166M +2,376,032 +173%
Envestnet Asset Management
27
Envestnet Asset Management
Illinois
$248M -$13.2M -189,512 -5%
Royal Bank of Canada
28
Royal Bank of Canada
Ontario, Canada
$241M +$64.6M +923,842 +37%
Wells Fargo
29
Wells Fargo
California
$226M +$6.95M +99,429 +3%
WCM Investment Management
30
WCM Investment Management
California
$185M -$94.3M -1,349,988 -34%
Janus Henderson Group
31
Janus Henderson Group
United Kingdom
$177M +$25.5M +364,569 +17%
UBS Group
32
UBS Group
Switzerland
$166M +$46.6M +666,403 +39%
MNA
33
Manning & Napier Advisors
New York
$150M -$63.1M -902,693 -30%
AllianceBernstein
34
AllianceBernstein
Tennessee
$146M -$7.13M -102,055 -5%
Acadian Asset Management
35
Acadian Asset Management
Massachusetts
$143M +$137M +1,961,764 +2,390%
Marshall Wace
36
Marshall Wace
United Kingdom
$140M +$43.6M +623,902 +45%
D.E. Shaw & Co
37
D.E. Shaw & Co
New York
$133M +$14.5M +207,151 +12%
Natixis Advisors
38
Natixis Advisors
Massachusetts
$128M -$27.8M -398,086 -18%
Citadel Advisors
39
Citadel Advisors
Florida
$128M -$15M -215,277 -11%
Point72 Asset Management
40
Point72 Asset Management
Connecticut
$118M +$34.8M +497,879 +42%
SC
41
Saturna Capital
Washington
$114M -$166K -2,380 -0.1%
American Century Companies
42
American Century Companies
Missouri
$109M -$32.2M -460,303 -23%
CIC
43
Crawford Investment Counsel
Georgia
$108M -$2M -28,637 -2%
OTPPB
44
Ontario Teachers' Pension Plan Board
Ontario, Canada
$96.9M +$96.9M +1,387,174 New
EIP
45
Epoch Investment Partners
New York
$92.5M -$47.1M -673,431 -34%
Renaissance Technologies
46
Renaissance Technologies
New York
$91.1M +$70.2M +1,004,573 +336%
Parnassus Investments
47
Parnassus Investments
California
$89.9M +$4.35M +62,220 +5%
Principal Financial Group
48
Principal Financial Group
Iowa
$84.1M +$391K +5,595 +0.5%
Assenagon Asset Management
49
Assenagon Asset Management
Luxembourg
$81.6M +$27.5M +392,843 +51%
Arrowstreet Capital
50
Arrowstreet Capital
Massachusetts
$80.8M -$170M -2,436,044 -68%
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