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AstraZeneca
AZN

1,287 hedge funds and large institutions have $37.9B invested in AstraZeneca in 2025 Q3 according to their latest regulatory filings, with 159 funds opening new positions, 546 increasing their positions, 359 reducing their positions, and 76 closing their positions.

New
Increased
Maintained
Reduced
Closed

109% more first-time investments, than exits

New positions opened: 159 | Existing positions closed: 76

91% more funds holding in top 10

Funds holding in top 10: 11 → 21 (+10)

84% more call options, than puts

Call options by funds: $559M | Put options by funds: $303M

52% more repeat investments, than reductions

Existing positions increased: 546 | Existing positions reduced: 359

9% more capital invested

Capital invested by funds: $34.7B → $37.9B (+$3.21B)

5% more funds holding

Funds holding: 1,222 → 1,287 (+65)

0.04% less ownership

Funds ownership: 8% → 7.96% (-0.04%)

Holders
1,287
Holders Change
+65
Holders Change %
+5.32%
% of All Funds
16.89%
Holding in Top 10
21
Holding in Top 10 Change
+10
Holding in Top 10 Change %
+90.91%
% of All Funds
0.28%
New
159
Increased
546
Reduced
359
Closed
76
Calls
$559M
Puts
$303M
Net Calls
+$256M
Net Calls Change
-$80.8M

Top Buyers

Rank Fund Capital Flow
1
Citigroup
Citigroup
New York
+$219M
2
Bank of Montreal
Bank of Montreal
Ontario, Canada
+$204M
3
Holocene Advisors
Holocene Advisors
New York
+$137M
4
Citadel Advisors
Citadel Advisors
Florida
+$133M
5
Goldman Sachs
Goldman Sachs
New York
+$126M

Top Sellers

Rank Fund Capital Flow
1
Jennison Associates
Jennison Associates
New York
-$642M
2
Capital International Investors
Capital International Investors
California
-$481M
3
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$213M
4
Wellington Management Group
Wellington Management Group
Massachusetts
-$154M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$127M
Name Holding Trade Value Shares
Change 		Change in
Stake
CM
376
Columbus Macro
Pennsylvania
$2.57M +$24.8K +164 +1%
AFG
377
Atomi Financial Group
New York
$2.53M +$682K +4,507 +38%
William Blair Investment Management
378
William Blair Investment Management
Illinois
$2.52M -$5K -33 -0.2%
WLIM
379
White Lighthouse Investment Management
Massachusetts
$2.51M – – –
HPC
380
HM Payson & Co
Maine
$2.5M -$186K -1,229 -7%
GWMR
381
GC Wealth Management RIA
Massachusetts
$2.5M +$120K +794 +5%
MCC
382
Money Concepts Capital
Florida
$2.47M +$14.7K +97 +0.6%
QI
383
Qtron Investments
Massachusetts
$2.43M -$134K -885 -5%
FFS
384
Founders Financial Securities
Maryland
$2.4M +$163K +1,074 +7%
CP
385
CenterBook Partners
Connecticut
$2.4M +$2.37M +15,632 New
OPA
386
Old Port Advisors
Maine
$2.37M +$90.2K +596 +4%
HI
387
Horizon Investments
North Carolina
$2.35M +$156K +1,028 +7%
DADC
388
D.A. Davidson & Co
Montana
$2.34M -$506K -3,345 -18%
VT
389
Vise Technologies
New York
$2.29M +$11.2K +74 +0.5%
OC
390
Oppenheimer & Co
New York
$2.28M +$156K +1,028 +7%
NAM
391
NTV Asset Management
West Virginia
$2.26M -$165K -1,088 -7%
UCFA
392
United Capital Financial Advisors
Texas
$2.26M -$695K -4,589 -24%
FIA
393
FNY Investment Advisers
New York
$2.24M – – –
PA
394
Pinnacle Associates
New York
$2.23M -$39.4K -260 -2%
HAG
395
HighPoint Advisor Group
Illinois
$2.23M +$167K +1,101 +8%
VNA
396
Valley National Advisers
Pennsylvania
$2.2M +$316K +2,087 +17%
SIM
397
SWP Investment Management
Ohio
$2.19M +$192K +1,270 +10%
EF
398
Empowered Funds
Pennsylvania
$2.16M +$2.13M +14,100 New
ES
399
Element Squared
Minnesota
$2.16M +$2.13M +14,056 New
JPWM
400
Jamison Private Wealth Management
Georgia
$2.15M – – –
14 15
16
17 18

AZN Hedge Fund Activity: Q3 2025 in Review

1,287 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in AstraZeneca (AZN) for Q3 2025, worth a combined $37.9B — up 9.2% from $34.7B a quarter earlier.

Buyers outnumbered sellers: 159 funds opened new AZN positions and 76 closed out — a net gain of 83 holders — while 546 added to existing stakes and 359 trimmed.

The largest buyer was Citigroup, adding an estimated $219M. The largest seller was Jennison Associates, cutting an estimated $642M.

  • 1,287 institutional investors held AstraZeneca (AZN) as of Q3 2025, up from 1,222 in Q2 2025.
  • Funds reported $37.9B of AstraZeneca stock for Q3 2025, up 9.2% quarter-over-quarter.
  • 159 funds opened new AstraZeneca positions in Q3 2025 and 76 closed out, a net change of +83 holders.
  • The largest AstraZeneca buyer in Q3 2025 was Citigroup, an estimated $219M added.
  • The largest AstraZeneca seller in Q3 2025 was Jennison Associates, an estimated $642M sold.

Based on aggregated 13F filings for Q3 2025.