Assembly Biosciences
ASMB
69 hedge funds and large institutions have $467M invested in Assembly Biosciences in 2025 Q4 according to their latest regulatory filings, with 22 funds opening new positions, 23 increasing their positions, 13 reducing their positions, and 8 closing their positions.
1,114% more call options, than puts
Call options by funds: $85K | Put options by funds: $7K
175% more first-time investments, than exits
New positions opened: 22 | Existing positions closed: 8
77% more repeat investments, than reductions
Existing positions increased: 23 | Existing positions reduced: 13
50% more funds holding in top 10
Funds holding in top 10: 2 → 3 (+1)
44% more capital invested
Capital invested by funds: $325M → $467M (+$142M)
21% more funds holding
Funds holding: 57 → 69 (+12)
75.93% less ownership
Funds ownership: 162.7% → 86.77% (-76%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
PBA
Paradigm Biocapital Advisors
New York
|
+$21.4M |
| 2 |
Point72 Asset Management
Stamford,
Connecticut
|
+$9.81M |
| 3 |
Adage Capital Partners
Boston,
Massachusetts
|
+$5.19M |
| 4 |
EP
Eversept Partners
New York
|
+$5.14M |
| 5 |
CM
Caption Management
Oklahoma City,
Oklahoma
|
+$3.43M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
FLSM
Frazier Life Sciences Management
Palo Alto,
California
|
-$11.7M |
| 2 |
Renaissance Technologies
New York
|
-$4.65M |
| 3 |
Blackstone Inc
New York
|
-$4.16M |
| 4 |
SSA
Schonfeld Strategic Advisors
New York
|
-$2.18M |
| 5 |
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
-$1.63M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
76
Wells Fargo
San Francisco,
California
| – | -$3.71K | -145 | Closed |
|
|
SS
77
SBI Securities
Tokyo,
Japan
| – | -$1.74K | -68 | Closed |
|
ASMB Hedge Fund Activity: Q4 2025 in Review
69 of the 8,228 institutional investors tracked by Wall St. Rank reported a position in Assembly Biosciences (ASMB) for Q4 2025, worth a combined $467M — up 44% from $325M a quarter earlier.
Buyers outnumbered sellers: 22 funds opened new ASMB positions and 8 closed out — a net gain of 14 holders — while 23 added to existing stakes and 13 trimmed.
The largest buyer was Paradigm Biocapital Advisors, opening a new position worth an estimated $21.4M. The largest seller was Frazier Life Sciences Management, exiting entirely with an estimated $11.7M sold.
- 69 institutional investors held Assembly Biosciences (ASMB) as of Q4 2025, up from 57 in Q3 2025.
- Funds reported $467M of Assembly Biosciences stock for Q4 2025, up 44% quarter-over-quarter.
- 22 funds opened new Assembly Biosciences positions in Q4 2025 and 8 closed out, a net change of +14 holders.
- The largest Assembly Biosciences buyer in Q4 2025 was Paradigm Biocapital Advisors, an estimated $21.4M added.
- The largest Assembly Biosciences seller in Q4 2025 was Frazier Life Sciences Management, an estimated $11.7M sold.
Based on aggregated 13F filings for Q4 2025.