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Apogee Therapeutics
APGE

174 hedge funds and large institutions have $2.37B invested in Apogee Therapeutics in 2025 Q3 according to their latest regulatory filings, with 26 funds opening new positions, 62 increasing their positions, 57 reducing their positions, and 33 closing their positions.

New
Increased
Maintained
Reduced
Closed

143% more call options, than puts

Call options by funds: $12.8M | Put options by funds: $5.26M

3.62% more ownership

Funds ownership: 125.6% → 129.22% (+3.6%)

9% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 57

4% less funds holding

Funds holding: 182 → 174 (-8)

6% less capital invested

Capital invested by funds: $2.51B → $2.37B (-$144M)

20% less funds holding in top 10

Funds holding in top 10: 5 → 4 (-1)

21% less first-time investments, than exits

New positions opened: 26 | Existing positions closed: 33

Holders
174
Holders Change
-8
Holders Change %
-4.4%
% of All Funds
2.28%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
26
Increased
62
Reduced
57
Closed
33
Calls
$12.8M
Puts
$5.26M
Net Calls
+$7.51M
Net Calls Change
+$23.4M

Top Buyers

Rank Fund Capital Flow
1
Wellington Management Group
Wellington Management Group
Massachusetts
+$35.1M
2
UBS Group
UBS Group
Switzerland
+$26.4M
3
Citadel Advisors
Citadel Advisors
Florida
+$25.7M
4
PBA
Paradigm Biocapital Advisors
New York
+$21.5M
5
SI
Sofinnova Investments
California
+$18.7M

Top Sellers

Rank Fund Capital Flow
1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$53.4M
2
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$40.3M
3
WP
Woodline Partners
California
-$31M
4
SL
Siren LLC
Connecticut
-$25.8M
5
Jennison Associates
Jennison Associates
New York
-$11.7M
Name Holding Trade Value Shares
Change 		Change in
Stake
Jennison Associates
176
Jennison Associates
New York
– -$11.7M -270,366 Closed
IC
177
Ikarian Capital
Texas
– -$10.1M -232,047 Closed
BFM
178
Boothbay Fund Management
New York
– -$3.7M -85,183 Closed
SC
179
Stempoint Capital
New York
– -$3.67M -84,466 Closed
WAM
180
Weiss Asset Management
Massachusetts
– -$3.57M -82,302 Closed
APM
181
Avidity Partners Management
Texas
– -$2.82M -65,000 Closed
CLGM
182
Capitolis Liquid Global Markets
New York
– -$2.73M -62,800 Closed
Renaissance Technologies
183
Renaissance Technologies
New York
– -$1.78M -41,100 Closed
First Trust Advisors
184
First Trust Advisors
Illinois
– -$1.63M -37,622 Closed
BOCH
185
Blue Owl Capital Holdings
New York
– -$1.52M -35,000 Closed
BHCM
186
Brevan Howard Capital Management
Jersey
– -$1.44M -33,085 Closed
PCMH
187
Polymer Capital Management (HK)
Hong Kong
– -$1.27M -29,268 Closed
LCG
188
Lisanti Capital Growth
New York
– -$800K -18,410 Closed
ACM
189
ADAR1 Capital Management
Texas
– -$785K -18,070 Closed
WG
190
Winton Group
United Kingdom
– -$635K -14,617 Closed
QC
191
Quadrature Capital
United Kingdom
– -$513K -11,829 Closed
FRM
192
Fox Run Management
Connecticut
– -$437K -10,055 Closed
Two Sigma Advisers
193
Two Sigma Advisers
New York
– -$274K -6,300 Closed
AI
194
Allostery Investments
Connecticut
– -$261K -6,000 Closed
AIM
195
Aigen Investment Management
New York
– -$238K -5,477 Closed
OF
196
Optimize Financial
California
– -$229K -5,284 Closed
HF
197
HRT Financial
New York
– -$226K -5,211 Closed
Allspring Global Investments
198
Allspring Global Investments
North Carolina
– -$218K -4,931 Closed
LCM
199
Legato Capital Management
California
– -$205K -4,720 Closed
PAS
200
Point72 Asia (Singapore)
Singapore
– -$166K -3,813 Closed
5 6 7
8
9

APGE Hedge Fund Activity: Q3 2025 in Review

174 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Apogee Therapeutics (APGE) for Q3 2025, worth a combined $2.37B — down 5.7% from $2.51B a quarter earlier.

Sellers outnumbered buyers: 33 funds closed out of APGE and 26 opened new positions — a net loss of 7 holders — while 57 trimmed existing stakes and 62 added.

The largest buyer was Wellington Management Group, adding an estimated $35.1M. The largest seller was Point72 Asset Management, exiting entirely with an estimated $53.4M sold.

  • 174 institutional investors held Apogee Therapeutics (APGE) as of Q3 2025, down from 182 in Q2 2025.
  • Funds reported $2.37B of Apogee Therapeutics stock for Q3 2025, down 5.7% quarter-over-quarter.
  • 26 funds opened new Apogee Therapeutics positions in Q3 2025 and 33 closed out, a net change of -7 holders.
  • The largest Apogee Therapeutics buyer in Q3 2025 was Wellington Management Group, an estimated $35.1M added.
  • The largest Apogee Therapeutics seller in Q3 2025 was Point72 Asset Management, an estimated $53.4M sold.

Based on aggregated 13F filings for Q3 2025.