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Agios Pharmaceuticals
AGIO

220 hedge funds and large institutions have $2.55B invested in Agios Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 43 funds opening new positions, 68 increasing their positions, 69 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more funds holding in top 10

Funds holding in top 10: 2 → 4 (+2)

24% more capital invested

Capital invested by funds: $2.05B → $2.55B (+$494M)

23% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 35

3% more funds holding

Funds holding: 214 → 220 (+6)

2.77% more ownership

Funds ownership: 106.52% → 109.29% (+2.8%)

9% more call options, than puts

Call options by funds: $85.2M | Put options by funds: $78.2M

1% less repeat investments, than reductions

Existing positions increased: 68 | Existing positions reduced: 69

Holders
220
Holders Change
+6
Holders Change %
+2.8%
% of All Funds
2.89%
Holding in Top 10
4
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+100%
% of All Funds
0.05%
New
43
Increased
68
Reduced
69
Closed
35
Calls
$85.2M
Puts
$78.2M
Net Calls
+$7.06M
Net Calls Change
+$4.49M

Top Buyers

1
Wellington Management Group
Wellington Management Group
Massachusetts
+$77.1M
2
PBA
Paradigm Biocapital Advisors
New York
+$57.6M
3
TCM
TCG Crossover Management
California
+$27.6M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$18.6M
5
EAM
Erste Asset Management
Austria
+$16.5M

Top Sellers

1
JP Morgan Chase
JP Morgan Chase
New York
-$31.8M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$23.2M
3
Citadel Advisors
Citadel Advisors
Florida
-$22.2M
4
O
OrbiMed
New York
-$18.6M
5
Marshall Wace
Marshall Wace
United Kingdom
-$17.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
Osaic Holdings
176
Osaic Holdings
Arizona
$13.5K -$414 -11 -3%
VCM
177
Versant Capital Management
Arizona
$12.7K – – –
Optiver Holding
178
Optiver Holding
Netherlands
$12.4K +$188 +5 +2%
BIA
179
Bell Investment Advisors
California
$12K – – –
CA
180
Clearstead Advisors
Ohio
$11.7K – – –
NS
181
NBC Securities
Alabama
$9.67K -$3.91K -104 -30%
SWM
182
Spire Wealth Management
Virginia
$9.23K – – –
GI
183
GAMMA Investing
California
$8.27K +$865 +23 +13%
CWP
184
Concord Wealth Partners
Virginia
$8.03K – – –
HIM
185
Hillsdale Investment Management
Ontario, Canada
$8.03K – – –
Daiwa Securities Group
186
Daiwa Securities Group
Japan
$8K – – –
Bessemer Group
187
Bessemer Group
New Jersey
$7K +$2.86K +76 +69%
FFA
188
Farther Finance Advisors
California
$6.46K +$376 +10 +7%
EP
189
Essential Partners
California
$4.62K – – –
RFP
190
Root Financial Partners
California
$4.25K +$3.99K +106 New
MG
191
Mather Group
Illinois
$3.81K +$3.57K +95 New
PWMG
192
Private Wealth Management Group
New Jersey
$3.37K – – –
RIL
193
Rothschild Investment LLC
Illinois
$3.01K -$564 -15 -17%
C
194
Covestor
United Kingdom
$3K +$2.29K +61 +2,033%
LFG
195
Larson Financial Group
Missouri
$2.97K +$2.78K +74 New
JWM
196
JPL Wealth Management
Colorado
$2.81K +$2.63K +70 New
EWA
197
EverSource Wealth Advisors
Alabama
$2.49K – – –
Federated Hermes
198
Federated Hermes
Pennsylvania
$2.13K -$20.5K -544 -91%
HHGA
199
Halbert Hargrove Global Advisors
California
$1.89K +$1.77K +47 New
PFBT
200
Parkside Financial Bank & Trust
Missouri
$1.81K – – –
6 7
8
9 10

AGIO Hedge Fund Activity: Q3 2025 in Review

220 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Agios Pharmaceuticals (AGIO) for Q3 2025, worth a combined $2.55B — up 24% from $2.05B a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new AGIO positions and 35 closed out — a net gain of 8 holders — while 68 added to existing stakes and 69 trimmed.

The largest buyer was Wellington Management Group, adding an estimated $77.1M. The largest seller was JP Morgan Chase, cutting an estimated $31.8M.

  • 220 institutional investors held Agios Pharmaceuticals (AGIO) as of Q3 2025, up from 214 in Q2 2025.
  • Funds reported $2.55B of Agios Pharmaceuticals stock for Q3 2025, up 24% quarter-over-quarter.
  • 43 funds opened new Agios Pharmaceuticals positions in Q3 2025 and 35 closed out, a net change of +8 holders.
  • The largest Agios Pharmaceuticals buyer in Q3 2025 was Wellington Management Group, an estimated $77.1M added.
  • The largest Agios Pharmaceuticals seller in Q3 2025 was JP Morgan Chase, an estimated $31.8M sold.

Based on aggregated 13F filings for Q3 2025.