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Agios Pharmaceuticals
AGIO

220 hedge funds and large institutions have $2.55B invested in Agios Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 43 funds opening new positions, 68 increasing their positions, 69 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more funds holding in top 10

Funds holding in top 10: 2 → 4 (+2)

24% more capital invested

Capital invested by funds: $2.05B → $2.55B (+$494M)

23% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 35

3% more funds holding

Funds holding: 214 → 220 (+6)

2.77% more ownership

Funds ownership: 106.52% → 109.29% (+2.8%)

9% more call options, than puts

Call options by funds: $85.2M | Put options by funds: $78.2M

1% less repeat investments, than reductions

Existing positions increased: 68 | Existing positions reduced: 69

Holders
220
Holders Change
+6
Holders Change %
+2.8%
% of All Funds
2.89%
Holding in Top 10
4
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+100%
% of All Funds
0.05%
New
43
Increased
68
Reduced
69
Closed
35
Calls
$85.2M
Puts
$78.2M
Net Calls
+$7.06M
Net Calls Change
+$4.49M

Top Buyers

1
Wellington Management Group
Wellington Management Group
Massachusetts
+$77.1M
2
PBA
Paradigm Biocapital Advisors
New York
+$57.6M
3
TCM
TCG Crossover Management
California
+$27.6M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$18.6M
5
EAM
Erste Asset Management
Austria
+$16.5M

Top Sellers

1
JP Morgan Chase
JP Morgan Chase
New York
-$31.8M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$23.2M
3
Citadel Advisors
Citadel Advisors
Florida
-$22.2M
4
O
OrbiMed
New York
-$18.6M
5
Marshall Wace
Marshall Wace
United Kingdom
-$17.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
QL
151
Quarry LP
New York
$201K +$188K +5,000 New
Carson Wealth (CWM LLC)
152
Carson Wealth (CWM LLC)
Nebraska
$192K -$18.6K -495 -9%
AIP
153
Ameritas Investment Partners
Nebraska
$189K -$44.9K -1,194 -20%
PNC Financial Services Group
154
PNC Financial Services Group
Pennsylvania
$183K +$5.08K +135 +3%
SCM
155
Sterling Capital Management
North Carolina
$157K +$90.1K +2,396 +158%
TC
156
Torno Capital
Massachusetts
$100K +$94K +2,500 New
Mirae Asset Global Investments
157
Mirae Asset Global Investments
South Korea
$90.2K +$339 +9 +0.4%
QT
158
Quantbot Technologies
New York
$79.3K +$74.3K +1,976 New
AB
159
Amalgamated Bank
New York
$79K – – –
KBC Group
160
KBC Group
Belgium
$70K – – –
BC
161
BIT Capital
Germany
$63.1K -$24.8K -659 -30%
TRCT
162
Tower Research Capital (TRC)
New York
$54.5K -$191K -5,083 -79%
NA
163
NewEdge Advisors
Louisiana
$51.1K – – –
GFM
164
GF Fund Management
China
$50.2K -$7.9K -210 -14%
FHC
165
First Horizon Corporation
Tennessee
$45.1K +$42.3K +1,124 New
AssetMark Inc
166
AssetMark Inc
California
$38.3K – – –
Nisa Investment Advisors
167
Nisa Investment Advisors
Missouri
$31.3K – – –
AAP
168
Arax Advisory Partners
Colorado
$28.2K +$25.9K +689 +5,300%
US Bancorp
169
US Bancorp
Minnesota
$22.8K – – –
S
170
SignatureFD
Georgia
$20.6K – – –
SAM
171
Smartleaf Asset Management
Massachusetts
$15.6K +$8.69K +231 +138%
Comerica Bank
172
Comerica Bank
Texas
$15K +$790 +21 +6%
HC
173
Hurley Capital
New York
$14.7K – – –
AP
174
Aspect Partners
Virginia
$14.5K – – –
ASN
175
Advisory Services Network
Georgia
$14K +$13.2K +350 New
5 6
7
8 9

AGIO Hedge Fund Activity: Q3 2025 in Review

220 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Agios Pharmaceuticals (AGIO) for Q3 2025, worth a combined $2.55B — up 24% from $2.05B a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new AGIO positions and 35 closed out — a net gain of 8 holders — while 68 added to existing stakes and 69 trimmed.

The largest buyer was Wellington Management Group, adding an estimated $77.1M. The largest seller was JP Morgan Chase, cutting an estimated $31.8M.

  • 220 institutional investors held Agios Pharmaceuticals (AGIO) as of Q3 2025, up from 214 in Q2 2025.
  • Funds reported $2.55B of Agios Pharmaceuticals stock for Q3 2025, up 24% quarter-over-quarter.
  • 43 funds opened new Agios Pharmaceuticals positions in Q3 2025 and 35 closed out, a net change of +8 holders.
  • The largest Agios Pharmaceuticals buyer in Q3 2025 was Wellington Management Group, an estimated $77.1M added.
  • The largest Agios Pharmaceuticals seller in Q3 2025 was JP Morgan Chase, an estimated $31.8M sold.

Based on aggregated 13F filings for Q3 2025.