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Agios Pharmaceuticals

237 hedge funds and large institutions have $1.67B invested in Agios Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 65 funds opening new positions, 79 increasing their positions, 70 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

191% more call options, than puts

Call options by funds: $133M | Put options by funds: $45.6M

48% more first-time investments, than exits

New positions opened: 65 | Existing positions closed: 44

13% more repeat investments, than reductions

Existing positions increased: 79 | Existing positions reduced: 70

8% more funds holding

Funds holding: 220237 (+17)

4.24% less ownership

Funds ownership: 109.29%105.05% (-4.2%)

25% less funds holding in top 10

Funds holding in top 10: 43 (-1)

35% less capital invested

Capital invested by funds: $2.55B → $1.67B (-$879M)

Holders
237
Holders Change
+17
Holders Change %
+7.73%
% of All Funds
2.88%
Holding in Top 10
3
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-25%
% of All Funds
0.04%
New
65
Increased
79
Reduced
70
Closed
44
Calls
$133M
Puts
$45.6M
Net Calls
+$87.2M
Net Calls Change
+$80.1M
Name Holding Trade Value Shares
Change
Change in
Stake
Janus Henderson Group
126
Janus Henderson Group
United Kingdom
$648K
Zurich Cantonal Bank
127
Zurich Cantonal Bank
Switzerland
$643K +$110K +3,144 +15%
Rockefeller Capital Management
128
Rockefeller Capital Management
New York
$574K +$177K +5,033 +31%
ORI
129
Oak Ridge Investments
Illinois
$545K -$189K -5,381 -21%
BHCM
130
Brevan Howard Capital Management
Jersey
$526K +$255K +7,265 +60%
Handelsbanken Fonder
131
Handelsbanken Fonder
Sweden
$526K
ET
132
Entropy Technologies
New York
$522K +$672K +19,163 New
VC
133
VarCov Co
Connecticut
$520K +$670K +19,104 New
Canada Pension Plan Investment Board
134
Canada Pension Plan Investment Board
Ontario, Canada
$495K +$639K +18,200 New
DMKJ
135
David M. Knott Jr
$490K +$632K +18,000 New
II
136
Inspire Investing
Idaho
$466K +$201K +5,720 +50%
WG
137
Winton Group
United Kingdom
$456K +$12.3K +351 +2%
State Board of Administration of Florida Retirement System
138
State Board of Administration of Florida Retirement System
Florida
$431K
PFSRSONJ
139
Police & Firemen's Retirement System of New Jersey
New Jersey
$426K +$246 +7 +0%
ASRS
140
Arizona State Retirement System
Arizona
$417K -$32.5K -925 -6%
SEI Investments
141
SEI Investments
Pennsylvania
$391K -$630K -17,948 -56%
TI
142
Tidal Investments
Wisconsin
$388K -$23.4K -667 -4%
AI
143
Atria Investments
North Carolina
$383K +$23.4K +667 +5%
AA
144
AlphaCentric Advisors
Puerto Rico
$358K +$461K +13,141 New
Royal Bank of Canada
145
Royal Bank of Canada
Ontario, Canada
$354K -$157K -4,472 -26%
ProShare Advisors
146
ProShare Advisors
Maryland
$351K +$41K +1,169 +10%
Envestnet Asset Management
147
Envestnet Asset Management
Illinois
$347K +$116K +3,312 +35%
CB
148
Commerce Bank
Missouri
$344K +$123K +3,497 +38%
BC
149
Bridgefront Capital
Texas
$344K +$444K +12,649 New
FRM
150
Fox Run Management
Connecticut
$342K +$441K +12,567 New