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Agios Pharmaceuticals
AGIO

220 hedge funds and large institutions have $2.55B invested in Agios Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 43 funds opening new positions, 68 increasing their positions, 69 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more funds holding in top 10

Funds holding in top 10: 2 → 4 (+2)

24% more capital invested

Capital invested by funds: $2.05B → $2.55B (+$494M)

23% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 35

3% more funds holding

Funds holding: 214 → 220 (+6)

2.77% more ownership

Funds ownership: 106.52% → 109.29% (+2.8%)

9% more call options, than puts

Call options by funds: $85.2M | Put options by funds: $78.2M

1% less repeat investments, than reductions

Existing positions increased: 68 | Existing positions reduced: 69

Holders
220
Holders Change
+6
Holders Change %
+2.8%
% of All Funds
2.89%
Holding in Top 10
4
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+100%
% of All Funds
0.05%
New
43
Increased
68
Reduced
69
Closed
35
Calls
$85.2M
Puts
$78.2M
Net Calls
+$7.06M
Net Calls Change
+$4.49M

Top Buyers

1
Wellington Management Group
Wellington Management Group
Massachusetts
+$77.1M
2
PBA
Paradigm Biocapital Advisors
New York
+$57.6M
3
TCM
TCG Crossover Management
California
+$27.6M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$18.6M
5
EAM
Erste Asset Management
Austria
+$16.5M

Top Sellers

1
JP Morgan Chase
JP Morgan Chase
New York
-$31.8M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$23.2M
3
Citadel Advisors
Citadel Advisors
Florida
-$22.2M
4
O
OrbiMed
New York
-$18.6M
5
Marshall Wace
Marshall Wace
United Kingdom
-$17.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
AllianceBernstein
76
AllianceBernstein
Tennessee
$2.47M +$1.24K +33 +0.1%
California State Teachers Retirement System (CalSTRS)
77
California State Teachers Retirement System (CalSTRS)
California
$2.46M +$513K +13,637 +29%
Two Sigma Investments
78
Two Sigma Investments
New York
$2.39M +$2.24M +59,629 New
MCM
79
Moore Capital Management
New York
$2.21M -$940K -25,000 -31%
New York State Common Retirement Fund
80
New York State Common Retirement Fund
New York
$2M +$402K +10,697 +27%
PFC
81
Phocas Financial Corp
California
$1.87M +$1.75M +46,608 New
Wells Fargo
82
Wells Fargo
California
$1.8M +$266K +7,060 +19%
Citigroup
83
Citigroup
New York
$1.75M -$484K -12,869 -23%
VRS
84
Virginia Retirement Systems
Virginia
$1.65M -$323K -8,600 -17%
DekaBank Deutsche Girozentrale
85
DekaBank Deutsche Girozentrale
Germany
$1.56M – – –
Ameriprise
86
Ameriprise
Minnesota
$1.54M -$520K -13,824 -26%
ACM
87
ADAR1 Capital Management
Texas
$1.49M +$41.4K +1,100 +3%
Mirae Asset Global ETFs Holdings
88
Mirae Asset Global ETFs Holdings
Hong Kong
$1.47M -$112K -2,987 -8%
AG
89
Algert Global
California
$1.44M -$2M -53,060 -60%
State of Wisconsin Investment Board
90
State of Wisconsin Investment Board
Wisconsin
$1.43M -$885K -23,527 -40%
Edgewood Management
91
Edgewood Management
Connecticut
$1.4M – – –
HCA
92
Harbor Capital Advisors
Illinois
$1.4M -$82.3K -2,189 -6%
MIM
93
MetLife Investment Management
New Jersey
$1.37M – – –
SEI Investments
94
SEI Investments
Pennsylvania
$1.3M +$826K +21,974 +213%
Victory Capital Management
95
Victory Capital Management
Texas
$1.21M +$30.8K +818 +3%
SG Americas Securities
96
SG Americas Securities
New York
$1.11M +$1.04M +27,650 New
AA
97
ALPS Advisors
Colorado
$1.11M -$140K -3,720 -12%
HWAM
98
Hennion & Walsh Asset Management
New Jersey
$1.02M +$395K +10,496 +70%
ORI
99
Oak Ridge Investments
Illinois
$1.02M -$446K -11,867 -32%
KCM
100
Kennedy Capital Management
Missouri
$989K -$454K -12,064 -33%
2 3
4
5 6

AGIO Hedge Fund Activity: Q3 2025 in Review

220 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Agios Pharmaceuticals (AGIO) for Q3 2025, worth a combined $2.55B — up 24% from $2.05B a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new AGIO positions and 35 closed out — a net gain of 8 holders — while 68 added to existing stakes and 69 trimmed.

The largest buyer was Wellington Management Group, adding an estimated $77.1M. The largest seller was JP Morgan Chase, cutting an estimated $31.8M.

  • 220 institutional investors held Agios Pharmaceuticals (AGIO) as of Q3 2025, up from 214 in Q2 2025.
  • Funds reported $2.55B of Agios Pharmaceuticals stock for Q3 2025, up 24% quarter-over-quarter.
  • 43 funds opened new Agios Pharmaceuticals positions in Q3 2025 and 35 closed out, a net change of +8 holders.
  • The largest Agios Pharmaceuticals buyer in Q3 2025 was Wellington Management Group, an estimated $77.1M added.
  • The largest Agios Pharmaceuticals seller in Q3 2025 was JP Morgan Chase, an estimated $31.8M sold.

Based on aggregated 13F filings for Q3 2025.