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Agios Pharmaceuticals

232 hedge funds and large institutions have $2.12B invested in Agios Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 36 funds opening new positions, 82 increasing their positions, 81 reducing their positions, and 36 closing their positions.

New
Increased
Maintained
Reduced
Closed

620% more call options, than puts

Call options by funds: $127M | Put options by funds: $17.6M

67% more funds holding in top 10

Funds holding in top 10: 35 (+2)

27% more capital invested

Capital invested by funds: $1.67B → $2.12B (+$452M)

2.54% more ownership

Funds ownership: 105.05%107.59% (+2.5%)

1% more repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 81

0% more first-time investments, than exits

New positions opened: 36 | Existing positions closed: 36

2% less funds holding

Funds holding: 237232 (-5)

Holders
232
Holders Change
-5
Holders Change %
-2.11%
% of All Funds
2.86%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.06%
New
36
Increased
82
Reduced
81
Closed
36
Calls
$127M
Puts
$17.6M
Net Calls
+$109M
Net Calls Change
+$22M
Name Holding Trade Value Shares
Change
Change in
Stake
HF
51
HRT Financial
New York
$6.61M +$1.39M +48,963 +33%
Qube Research & Technologies (QRT)
52
Qube Research & Technologies (QRT)
United Kingdom
$6.35M -$5.41M -190,706 -50%
Bank of New York Mellon
53
Bank of New York Mellon
New York
$6.32M -$286K -10,102 -5%
Group One Trading
54
Group One Trading
Illinois
$5.86M +$189K +6,665 +4%
TAM
55
TFG Asset Management
Cayman Islands
$5.58M +$80K +2,821 +2%
XT
56
XTX Topco
Cayman Islands
$5.44M +$3.26M +114,841 +249%
Invesco
57
Invesco
Georgia
$5.12M +$251K +8,850 +6%
Man Group
58
Man Group
United Kingdom
$4.88M +$4.09M +144,297 New
EP
59
Edgestream Partners
New Jersey
$4.86M -$688K -24,267 -14%
ACM
60
ADAR1 Capital Management
Texas
$4.76M -$1.34M -47,328 -25%
JP Morgan Chase
61
JP Morgan Chase
New York
$4.49M -$2.84M -100,219 -40%
UBS Group
62
UBS Group
Switzerland
$4.48M +$167K +5,875 +5%
Capital Fund Management (CFM)
63
Capital Fund Management (CFM)
France
$4.38M +$2.66M +93,743 +262%
EAM
64
Exome Asset Management
New York
$4.23M -$337K -11,882 -9%
American Century Companies
65
American Century Companies
Missouri
$4.07M -$886K -31,233 -21%
Pictet Asset Management
66
Pictet Asset Management
Switzerland
$3.85M -$2.16M -76,205 -37%
UBS AM
67
UBS AM
Illinois
$3.74M +$104K +3,683 +3%
Swiss National Bank
68
Swiss National Bank
Switzerland
$3.68M
EIM
69
Essex Investment Management
Massachusetts
$3.49M +$2.93M +103,177 New
Rafferty Asset Management
70
Rafferty Asset Management
New York
$3.48M -$135K -4,749 -4%
TCM
71
Tang Capital Management
California
$3.38M +$2.84M +100,000 New
DMKJ
72
David M. Knott Jr
$3.15M +$2.13M +75,058 +417%
TI
73
Trexquant Investment
Connecticut
$2.55M -$4.29M -151,302 -67%
WP
74
Woodline Partners
California
$2.52M
RhumbLine Advisers
75
RhumbLine Advisers
Massachusetts
$2.48M -$22.2K -784 -1%

AGIO Hedge Fund Activity: Q1 2026 in Review

232 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Agios Pharmaceuticals (AGIO) for Q1 2026, worth a combined $2.12B — up 27% from $1.67B a quarter earlier.

Fund positioning in AGIO was balanced in Q1 2026: 36 funds opened new positions, 36 closed out, 82 added to existing stakes and 81 trimmed.

The largest buyer was Lynx1 Capital Management, adding an estimated $71.8M. The largest seller was TCG Crossover Management, exiting entirely with an estimated $32.2M sold.

  • 232 institutional investors held Agios Pharmaceuticals (AGIO) as of Q1 2026, down from 237 in Q4 2025.
  • Funds reported $2.12B of Agios Pharmaceuticals stock for Q1 2026, up 27% quarter-over-quarter.
  • 36 funds opened new Agios Pharmaceuticals positions in Q1 2026 and 36 closed out, a net change of 0 holders.
  • The largest Agios Pharmaceuticals buyer in Q1 2026 was Lynx1 Capital Management, an estimated $71.8M added.
  • The largest Agios Pharmaceuticals seller in Q1 2026 was TCG Crossover Management, an estimated $32.2M sold.

Based on aggregated 13F filings for Q1 2026.