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Agios Pharmaceuticals
AGIO

220 hedge funds and large institutions have $2.55B invested in Agios Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 43 funds opening new positions, 68 increasing their positions, 69 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more funds holding in top 10

Funds holding in top 10: 2 → 4 (+2)

24% more capital invested

Capital invested by funds: $2.05B → $2.55B (+$494M)

23% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 35

3% more funds holding

Funds holding: 214 → 220 (+6)

2.77% more ownership

Funds ownership: 106.52% → 109.29% (+2.8%)

9% more call options, than puts

Call options by funds: $85.2M | Put options by funds: $78.2M

1% less repeat investments, than reductions

Existing positions increased: 68 | Existing positions reduced: 69

Holders
220
Holders Change
+6
Holders Change %
+2.8%
% of All Funds
2.89%
Holding in Top 10
4
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+100%
% of All Funds
0.05%
New
43
Increased
68
Reduced
69
Closed
35
Calls
$85.2M
Puts
$78.2M
Net Calls
+$7.06M
Net Calls Change
+$4.49M

Top Buyers

1
Wellington Management Group
Wellington Management Group
Massachusetts
+$77.1M
2
PBA
Paradigm Biocapital Advisors
New York
+$57.6M
3
TCM
TCG Crossover Management
California
+$27.6M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$18.6M
5
EAM
Erste Asset Management
Austria
+$16.5M

Top Sellers

1
JP Morgan Chase
JP Morgan Chase
New York
-$31.8M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$23.2M
3
Citadel Advisors
Citadel Advisors
Florida
-$22.2M
4
O
OrbiMed
New York
-$18.6M
5
Marshall Wace
Marshall Wace
United Kingdom
-$17.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
TI
226
Trexquant Investment
Connecticut
– -$3.27M -98,401 Closed
SAM
227
Silvercrest Asset Management
New York
– -$2.75M -82,679 Closed
Capital Fund Management (CFM)
228
Capital Fund Management (CFM)
France
– -$2.28M -68,502 Closed
Susquehanna International Group
229
Susquehanna International Group
Pennsylvania
– -$2.56M -68,103 Closed
Qube Research & Technologies (QRT)
230
Qube Research & Technologies (QRT)
United Kingdom
– -$2.24M -67,379 Closed
UOC
231
UBS O'Connor
Illinois
– -$1.89M -56,810 Closed
Franklin Resources
232
Franklin Resources
California
– -$1.67M -50,108 Closed
PAM
233
Panagora Asset Management
Massachusetts
– -$1.57M -47,190 Closed
SSA
234
Schonfeld Strategic Advisors
New York
– -$1.54M -46,346 Closed
GIM
235
Granahan Investment Management
Massachusetts
– -$1.39M -41,886 Closed
FRM
236
Fox Run Management
Connecticut
– -$589K -17,707 Closed
Thrivent Financial for Lutherans
237
Thrivent Financial for Lutherans
Minnesota
– -$583K -17,526 Closed
EGM
238
Engineers Gate Manager
New York
– -$550K -16,548 Closed
CC
239
Centiva Capital
New York
– -$566K -15,040 Closed
PAMP
240
Polar Asset Management Partners
Ontario, Canada
– -$489K -14,700 Closed
HT
241
Headlands Technologies
Illinois
– -$421K -12,644 Closed
TSS
242
Two Sigma Securities
New York
– -$288K -8,646 Closed
IC
243
IEQ Capital
California
– -$269K -8,086 Closed
JG
244
Jain Global
New York
– -$258K -7,749 Closed
Norges Bank
245
Norges Bank
Norway
– -$225K -6,756 Closed
WSFS
246
Wilmington Savings Fund Society
Delaware
– -$62.7K -1,885 Closed
BIG
247
Brooklyn Investment Group
New York
– -$37.6K -1,130 Closed
SO
248
STRS Ohio
Ohio
– -$36.6K -1,100 Closed
Lazard Asset Management
249
Lazard Asset Management
New York
– -$17K -534 Closed
Raymond James Financial
250
Raymond James Financial
Florida
– -$14.7K -442 Closed
7 8 9
10
11

AGIO Hedge Fund Activity: Q3 2025 in Review

220 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Agios Pharmaceuticals (AGIO) for Q3 2025, worth a combined $2.55B — up 24% from $2.05B a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new AGIO positions and 35 closed out — a net gain of 8 holders — while 68 added to existing stakes and 69 trimmed.

The largest buyer was Wellington Management Group, adding an estimated $77.1M. The largest seller was JP Morgan Chase, cutting an estimated $31.8M.

  • 220 institutional investors held Agios Pharmaceuticals (AGIO) as of Q3 2025, up from 214 in Q2 2025.
  • Funds reported $2.55B of Agios Pharmaceuticals stock for Q3 2025, up 24% quarter-over-quarter.
  • 43 funds opened new Agios Pharmaceuticals positions in Q3 2025 and 35 closed out, a net change of +8 holders.
  • The largest Agios Pharmaceuticals buyer in Q3 2025 was Wellington Management Group, an estimated $77.1M added.
  • The largest Agios Pharmaceuticals seller in Q3 2025 was JP Morgan Chase, an estimated $31.8M sold.

Based on aggregated 13F filings for Q3 2025.