Adagio Medical Holdings
ADGM
21 hedge funds and large institutions have $17.2M invested in Adagio Medical Holdings in 2025 Q4 according to their latest regulatory filings, with 11 funds opening new positions, 5 increasing their positions, 2 reducing their positions, and 5 closing their positions.
150% more repeat investments, than reductions
Existing positions increased: 5 | Existing positions reduced: 2
120% more first-time investments, than exits
New positions opened: 11 | Existing positions closed: 5
40% more funds holding
Funds holding: 15 → 21 (+6)
2.49% more ownership
Funds ownership: 75.67% → 78.16% (+2.5%)
24% less capital invested
Capital invested by funds: $22.6M → $17.2M (-$5.36M)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SCM
Sio Capital Management
New York
|
+$1.53M |
| 2 |
Alyeska Investment Group
Chicago,
Illinois
|
+$1.38M |
| 3 |
ACM
ADAR1 Capital Management
Austin,
Texas
|
+$1.38M |
| 4 |
SCM
Silverarc Capital Management
Boston,
Massachusetts
|
+$611K |
| 5 |
AC
Armistice Capital
New York
|
+$567K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RI
RTW Investments
New York
|
-$406K |
| 2 |
OM
Opaleye Management
Boston,
Massachusetts
|
-$109K |
| 3 |
Renaissance Technologies
New York
|
-$52.4K |
| 4 |
SCM
Shaolin Capital Management
Miami,
Florida
|
-$10.5K |
| 5 |
UBS Group
Zurich,
Switzerland
|
-$161 |
ADGM Hedge Fund Activity: Q4 2025 in Review
21 of the 99 institutional investors tracked by Wall St. Rank reported a position in Adagio Medical Holdings (ADGM) for Q4 2025, worth a combined $17.2M — down 24% from $22.6M a quarter earlier.
Buyers outnumbered sellers: 11 funds opened new ADGM positions and 5 closed out — a net gain of 6 holders — while 5 added to existing stakes and 2 trimmed.
The largest buyer was Sio Capital Management, opening a new position worth an estimated $1.53M. The largest seller was RTW Investments, exiting entirely with an estimated $406K sold.
- 21 institutional investors held Adagio Medical Holdings (ADGM) as of Q4 2025, up from 15 in Q3 2025.
- Funds reported $17.2M of Adagio Medical Holdings stock for Q4 2025, down 24% quarter-over-quarter.
- 11 funds opened new Adagio Medical Holdings positions in Q4 2025 and 5 closed out, a net change of +6 holders.
- The largest Adagio Medical Holdings buyer in Q4 2025 was Sio Capital Management, an estimated $1.53M added.
- The largest Adagio Medical Holdings seller in Q4 2025 was RTW Investments, an estimated $406K sold.
Based on aggregated 13F filings for Q4 2025.