Two Sigma Investments
XERS icon

Two Sigma Investments’s Xeris Biopharma Holdings XERS Stock Holding History

Two Sigma Investments’s Portfolio XERS Stock Details XERS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$11.2M Buy
1,924,202
+191,535
+11% +$1.27M 0.01% 1337
2025
Q4 		$13.6M Buy
1,732,667
+118,088
+7% +$929K 0.02% 936
2025
Q3 		$13.1M Buy
1,614,579
+399,880
+33% +$2.66M 0.02% 817
2025
Q2 		$5.67M Buy
1,214,699
+324,362
+36% +$1.49M 0.01% 1156
2025
Q1 		$4.89M Buy
+890,337
New +$3.59M 0.01% 1146
2024
Q3 		– Sell
-26,803
Closed -$60.3K – 3362
2024
Q2 		$60.3K Sell
26,803
-103,061
-79% -$208K ﹤0.01% 2871
2024
Q1 		$287K Buy
129,864
+32,515
+33% +$84.1K ﹤0.01% 2577
2023
Q4 		$229K Sell
97,349
-12,577
-11% -$23.2K ﹤0.01% 2781
2023
Q3 		$204K Sell
109,926
-92,286
-46% -$211K ﹤0.01% 2634
2023
Q2 		$530K Buy
+202,212
New +$515K ﹤0.01% 2303
2022
Q2 		– Sell
-150,109
Closed -$384K – 2985
2022
Q1 		$384K Buy
+150,109
New +$367K ﹤0.01% 2133
2021
Q1 		– Sell
-127,094
Closed -$625K – 4294
2020
Q4 		$625K Buy
+127,094
New +$636K ﹤0.01% 2341
2020
Q3 		– Sell
-119,071
Closed -$317K – 3627
2020
Q2 		$317K Sell
119,071
-59,579
-33% -$207K ﹤0.01% 2343
2020
Q1 		$348K Buy
178,650
+153,498
+610% +$660K ﹤0.01% 2192
2019
Q4 		$177K Buy
+25,152
New +$208K ﹤0.01% 3447
2019
Q2 		– Sell
-75,022
Closed -$753K – 3716
2019
Q1 		$753K Buy
+75,022
New +$961K ﹤0.01% 2000

Other funds holding XERS

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $166B AUM 43.98% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT) London, United Kingdom $89.9B AUM 20.22% 1-Year Est. Return
RA
Rosalind Advisors Toronto, Ontario, Canada $249M AUM 80.12% 1-Year Est. Return
N
Nuveen Charlotte, North Carolina $369B AUM 31.66% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

Two Sigma Investments's XERS Position: Q1 2026 in Review

Two Sigma Investments increased its Xeris Biopharma Holdings (XERS) stake by 11% in Q1 2026, buying an estimated $1.27M and bringing the position to 1,924,202 shares worth $11.2M. The position accounts for 0.01% of the portfolio, ranked #1337.

Two Sigma Investments first reported a position in XERS in Q1 2019 and has held it in 16 quarters since. The position peaked at $13.6M in Q4 2025. 237 funds tracked by Wall St. Rank hold XERS as of Q1 2026.

  • Two Sigma Investments held 1,924,202 shares of Xeris Biopharma Holdings worth $11.2M as of Q1 2026.
  • Two Sigma Investments bought 191,535 Xeris Biopharma Holdings shares in Q1 2026, an estimated $1.27M.
  • Xeris Biopharma Holdings made up 0.01% of Two Sigma Investments's portfolio in Q1 2026, its #1337 holding.
  • Two Sigma Investments first reported a position in Xeris Biopharma Holdings in Q1 2019 and has held it in 16 quarters since.
  • Two Sigma Investments's Xeris Biopharma Holdings position peaked at $13.6M in Q4 2025.
  • 237 funds tracked by Wall St. Rank held Xeris Biopharma Holdings as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.