Two Sigma Investments
SMLR

Two Sigma Investments’s Semler Scientific SMLR Stock Holding History

Two Sigma Investments’s Portfolio SMLR Stock Details SMLR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-24,586
Closed -$738K – 4397
2025
Q3 		$738K Sell
24,586
-56,194
-70% -$1.93M ﹤0.01% 2779
2025
Q2 		$3.13M Buy
80,780
+55,875
+224% +$1.99M 0.01% 1535
2025
Q1 		$902K Buy
+24,905
New +$1.17M ﹤0.01% 2232
2024
Q1 		– Sell
-22,832
Closed -$1.01M – 3363
2023
Q4 		$1.01M Sell
22,832
-26,804
-54% -$963K ﹤0.01% 2069
2023
Q3 		$1.26M Buy
49,636
+21,906
+79% +$570K ﹤0.01% 1801
2023
Q2 		$728K Buy
+27,730
New +$731K ﹤0.01% 2140
2022
Q3 		– Sell
-12,365
Closed -$348K – 2794
2022
Q2 		$348K Buy
+12,365
New +$442K ﹤0.01% 1969

Other funds holding SMLR

Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
ICP
Interchange Capital Partners Pittsburgh, Pennsylvania $532M AUM 26.57% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
WAM
Weiss Asset Management Boston, Massachusetts $5.91B AUM 42.42% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
LP
LMR Partners London, United Kingdom $45.4B AUM 60.68% 1-Year Est. Return
Charles Schwab
Charles Schwab San Francisco, California $654B AUM 26.35% 1-Year Est. Return
SSA
Schonfeld Strategic Advisors New York $14.2B AUM 37.17% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $935B AUM
Capital International Investors
Capital International Investors Los Angeles, California $427B AUM 29.17% 1-Year Est. Return

Two Sigma Investments's SMLR Position: Q4 2025 in Review

Two Sigma Investments sold out of Semler Scientific (SMLR) in Q4 2025, closing a stake of 24,586 shares — an estimated $738K sold.

Two Sigma Investments first reported a position in SMLR in Q2 2022 and held it in 7 quarters. The position peaked at $3.13M in Q2 2025. 109 funds tracked by Wall St. Rank hold SMLR as of Q4 2025.

  • Two Sigma Investments reported no remaining Semler Scientific position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Investments sold 24,586 Semler Scientific shares in Q4 2025, an estimated $738K.
  • Two Sigma Investments first reported a position in Semler Scientific in Q2 2022 and held it in 7 quarters.
  • Two Sigma Investments's Semler Scientific position peaked at $3.13M in Q2 2025.
  • 109 funds tracked by Wall St. Rank held Semler Scientific as of Q4 2025.

Based on Two Sigma Investments's 13F filing for Q4 2025, filed 17 Feb 2026.