Two Sigma Investments’s Phio Pharmaceuticals PHIO Stock Holding History

Two Sigma Investments’s Portfolio PHIO Stock Details PHIO Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$39.6K	Buy	32,495 +18,001	+124%	+$20.5K	﹤0.01%	4471
2025 Q4	$15.2K	Buy	+14,494	New	+$23.2K	﹤0.01%	4011
2023 Q1	–	Sell	-207	Closed	-$8.33K	–	3153
2022 Q4	$8.33K	Sell	207 -8	-4%	-$410	﹤0.01%	2737
2022 Q3	$13K	Sell	215 -42	-16%	-$3.18K	﹤0.01%	2402
2022 Q2	$20K	Buy	+257	New	+$24.2K	﹤0.01%	2406
2022 Q1	–	Sell	-1,192	Closed	-$129K	–	3926
2021 Q4	$129K	Buy	1,192 +802	+206%	+$128K	﹤0.01%	4013
2021 Q3	$86K	Buy	390 +2	+0.5%	+$418	﹤0.01%	4100
2021 Q2	$95K	Buy	+388	New	+$95.6K	﹤0.01%	3904

Other funds holding PHIO

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Jane Street New York $777B AUM 61.18% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Cetera Investment Advisers Schaumburg, Illinois $94B AUM 20.14% 1-Year Est. Return

VFT

Vanguard Fiduciary Trust Malvern, Pennsylvania $396B AUM

HRT Financial New York $40.1B AUM 58.22% 1-Year Est. Return

SRL

Scientech Research LLC Jersey City, New Jersey $120M AUM 73.62% 1-Year Est. Return

UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return

XTX Topco George Town, Cayman Islands $5.75B AUM 30.56% 1-Year Est. Return

Northern Trust Chicago, Illinois $757B AUM 28.64% 1-Year Est. Return

Two Sigma Investments's PHIO Position: Q1 2026 in Review

Two Sigma Investments increased its Phio Pharmaceuticals (PHIO) stake by 124% in Q1 2026, buying an estimated $20.5K and bringing the position to 32,495 shares worth $39.6K. The position accounts for ﹤0.01% of the portfolio, ranked #4471.

Two Sigma Investments first reported a position in PHIO in Q2 2021 and has held it in 8 quarters since. The position peaked at $129K in Q4 2021. 24 funds tracked by Wall St. Rank hold PHIO as of Q1 2026.

Two Sigma Investments held 32,495 shares of Phio Pharmaceuticals worth $39.6K as of Q1 2026.
Two Sigma Investments bought 18,001 Phio Pharmaceuticals shares in Q1 2026, an estimated $20.5K.
Phio Pharmaceuticals made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4471 holding.
Two Sigma Investments first reported a position in Phio Pharmaceuticals in Q2 2021 and has held it in 8 quarters since.
Two Sigma Investments's Phio Pharmaceuticals position peaked at $129K in Q4 2021.
24 funds tracked by Wall St. Rank held Phio Pharmaceuticals as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.