Two Sigma Investments
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Two Sigma Investments’s Outlook Therapeutics OTLK Stock Holding History

Two Sigma Investments’s Portfolio OTLK Stock Details OTLK Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-11,356
Closed -$12K – 4326
2025
Q3 		$12K Buy
+11,356
New +$19.6K ﹤0.01% 3620
2025
Q2 		– Sell
-20,719
Closed -$25.3K – 3435
2025
Q1 		$25.3K Buy
20,719
+10,128
+96% +$17.8K ﹤0.01% 3089
2024
Q4 		$20K Buy
+10,591
New +$43.6K ﹤0.01% 3110
2024
Q1 		– Sell
-617
Closed -$4.86K – 3282
2023
Q4 		$4.86K Buy
+617
New +$5.22K ﹤0.01% 3104
2022
Q2 		– Sell
-11,806
Closed -$420K – 2829
2022
Q1 		$420K Sell
11,806
-26,701
-69% -$834K ﹤0.01% 2098
2021
Q4 		$1.05M Buy
38,507
+24,930
+184% +$889K ﹤0.01% 2528
2021
Q3 		$589K Sell
13,577
-30,957
-70% -$1.49M ﹤0.01% 3100
2021
Q2 		$2.22M Sell
44,534
-17,668
-28% -$820K 0.01% 1774
2021
Q1 		$2.8M Buy
62,202
+53,321
+600% +$2.04M 0.01% 1443
2020
Q4 		$231K Buy
8,881
+2,990
+51% +$62.5K ﹤0.01% 3033
2020
Q3 		$85K Buy
+5,891
New +$131K ﹤0.01% 2955

Other funds holding OTLK

SSA
Schonfeld Strategic Advisors New York $14.2B AUM 37.17% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
GWM
Gilpin Wealth Management Denver, Colorado $126M AUM
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Marshall Wace
Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
Susquehanna International Group
Susquehanna International Group Bala Cynwyd, Pennsylvania $893B AUM 36.07% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Two Sigma Investments's OTLK Position: Q4 2025 in Review

Two Sigma Investments sold out of Outlook Therapeutics (OTLK) in Q4 2025, closing a stake of 11,356 shares — an estimated $12K sold.

Two Sigma Investments first reported a position in OTLK in Q3 2020 and held it in 11 quarters. The position peaked at $2.8M in Q1 2021. 53 funds tracked by Wall St. Rank hold OTLK as of Q4 2025.

  • Two Sigma Investments reported no remaining Outlook Therapeutics position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Investments sold 11,356 Outlook Therapeutics shares in Q4 2025, an estimated $12K.
  • Two Sigma Investments first reported a position in Outlook Therapeutics in Q3 2020 and held it in 11 quarters.
  • Two Sigma Investments's Outlook Therapeutics position peaked at $2.8M in Q1 2021.
  • 53 funds tracked by Wall St. Rank held Outlook Therapeutics as of Q4 2025.

Based on Two Sigma Investments's 13F filing for Q4 2025, filed 17 Feb 2026.