Two Sigma Investments
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Two Sigma Investments’s Nuvalent NUVL Stock Holding History

Two Sigma Investments’s Portfolio NUVL Stock Details NUVL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$10.5M Buy
+102,118
New +$10.4M 0.01% 1377
2025
Q3 		– Sell
-8,959
Closed -$684K – 3835
2025
Q2 		$684K Sell
8,959
-150,164
-94% -$11M ﹤0.01% 2447
2025
Q1 		$11.3M Sell
159,123
-54,759
-26% -$4.28M 0.02% 721
2024
Q4 		$16.7M Sell
213,882
-48,506
-18% -$4.53M 0.04% 541
2024
Q3 		$26.8M Sell
262,388
-20,274
-7% -$1.68M 0.06% 394
2024
Q2 		$21.4M Buy
282,662
+248,913
+738% +$17.7M 0.05% 433
2024
Q1 		$2.53M Buy
33,749
+18,649
+124% +$1.48M 0.01% 1324
2023
Q4 		$1.11M Hold
15,100
– – ﹤0.01% 2008
2023
Q3 		$694K Hold
15,100
– – ﹤0.01% 2132
2023
Q2 		$637K Buy
15,100
+2,000
+15% +$75.6K ﹤0.01% 2212
2023
Q1 		$342K Sell
13,100
-13,632
-51% -$403K ﹤0.01% 2363
2022
Q4 		$796K Buy
+26,732
New +$746K ﹤0.01% 1820

Other funds holding NUVL

DM
Deerfield Management New York $8.48B AUM 99.04% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return
RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return

Two Sigma Investments's NUVL Position: Q1 2026 in Review

Two Sigma Investments opened a new position in Nuvalent (NUVL) in Q1 2026: 102,118 shares worth $10.5M. The stake represents 0.01% of the portfolio and ranks #1377 among its holdings. This is a return to the name: Two Sigma Investments previously reported a position in NUVL as recently as Q2 2025.

Two Sigma Investments first reported a position in NUVL in Q4 2022 and has held it in 12 quarters since. The position peaked at $26.8M in Q3 2024. 263 funds tracked by Wall St. Rank hold NUVL as of Q1 2026.

  • Two Sigma Investments held 102,118 shares of Nuvalent worth $10.5M as of Q1 2026.
  • Nuvalent was a new Two Sigma Investments position in Q1 2026.
  • Nuvalent made up 0.01% of Two Sigma Investments's portfolio in Q1 2026, its #1377 holding.
  • Two Sigma Investments first reported a position in Nuvalent in Q4 2022 and has held it in 12 quarters since.
  • Two Sigma Investments's Nuvalent position peaked at $26.8M in Q3 2024.
  • 263 funds tracked by Wall St. Rank held Nuvalent as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.