Two Sigma Investments
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Two Sigma Investments’s Seres Therapeutics MCRB Stock Holding History

Two Sigma Investments’s Portfolio MCRB Stock Details MCRB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$167K Sell
18,794
-6,955
-27% -$81.5K ﹤0.01% 4314
2025
Q4 		$383K Buy
+25,749
New +$449K ﹤0.01% 3456
2025
Q2 		– Sell
-1,616
Closed -$22.6K – 3384
2025
Q1 		$22.6K Buy
1,616
+395
+32% +$6.18K ﹤0.01% 3093
2024
Q4 		$20.3K Buy
+1,221
New +$19.8K ﹤0.01% 3108
2024
Q1 		– Sell
-17,479
Closed -$489K – 3235
2023
Q4 		$489K Buy
17,479
+16,878
+2,808% +$443K ﹤0.01% 2474
2023
Q3 		$28.6K Buy
+601
New +$45.9K ﹤0.01% 2852
2022
Q3 		– Sell
-16,803
Closed -$1.15M – 2672
2022
Q2 		$1.15M Buy
16,803
+10,395
+162% +$896K ﹤0.01% 1480
2022
Q1 		$912K Buy
6,408
+3,081
+93% +$474K ﹤0.01% 1750
2021
Q4 		$554K Sell
3,327
-46,644
-93% -$7.41M ﹤0.01% 3148
2021
Q3 		$6.96M Buy
49,971
+42,011
+528% +$8.22M 0.02% 990
2021
Q2 		$3.8M Sell
7,960
-2,535
-24% -$1.07M 0.01% 1373
2021
Q1 		$4.32M Buy
10,495
+3,469
+49% +$1.6M 0.01% 1154
2020
Q4 		$3.44M Buy
7,026
+5,660
+414% +$3.31M 0.01% 1146
2020
Q3 		$774K Sell
1,366
-6,556
-83% -$2.18M ﹤0.01% 1932
2020
Q2 		$754K Buy
7,922
+5,659
+250% +$497K ﹤0.01% 1720
2020
Q1 		$162K Sell
2,263
-3,316
-59% -$222K ﹤0.01% 2722
2019
Q4 		$385K Buy
5,579
+784
+16% +$58.1K ﹤0.01% 3001
2019
Q3 		$385K Sell
4,795
-3,767
-44% -$249K ﹤0.01% 2759
2019
Q2 		$551K Buy
8,562
+5,872
+218% +$557K ﹤0.01% 2425
2019
Q1 		$370K Buy
2,690
+1,787
+198% +$218K ﹤0.01% 2460
2018
Q4 		$82K Buy
+903
New +$126K ﹤0.01% 2832
2018
Q3 		– Sell
-1,240
Closed -$213K – 3432
2018
Q2 		$213K Buy
+1,240
New +$203K ﹤0.01% 3109
2018
Q1 		– Sell
-1,922
Closed -$390K – 3365
2017
Q4 		$390K Buy
1,922
+1,362
+243% +$280K ﹤0.01% 2588
2017
Q3 		$180K Buy
+560
New +$153K ﹤0.01% 2606

Other funds holding MCRB

FP
Flagship Pioneering Cambridge, Massachusetts $1.16B AUM 67.93% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Marshall Wace
Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return
Vontobel Holding
Vontobel Holding Zurich, Switzerland $29.1B AUM 22.79% 1-Year Est. Return
Susquehanna International Group
Susquehanna International Group Bala Cynwyd, Pennsylvania $893B AUM 36.07% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
American Century Companies
American Century Companies Kansas City, Missouri $194B AUM 35% 1-Year Est. Return
VFT
Vanguard Fiduciary Trust Malvern, Pennsylvania $396B AUM
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Two Sigma Investments's MCRB Position: Q1 2026 in Review

Two Sigma Investments reduced its Seres Therapeutics (MCRB) stake by 27% in Q1 2026, selling an estimated $81.5K and leaving 18,794 shares worth $167K. The position accounts for ﹤0.01% of the portfolio, ranked #4314.

Two Sigma Investments first reported a position in MCRB in Q3 2017 and has held it in 24 quarters since. The position peaked at $6.96M in Q3 2021. 33 funds tracked by Wall St. Rank hold MCRB as of Q1 2026.

  • Two Sigma Investments held 18,794 shares of Seres Therapeutics worth $167K as of Q1 2026.
  • Two Sigma Investments sold 6,955 Seres Therapeutics shares in Q1 2026, an estimated $81.5K.
  • Seres Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4314 holding.
  • Two Sigma Investments first reported a position in Seres Therapeutics in Q3 2017 and has held it in 24 quarters since.
  • Two Sigma Investments's Seres Therapeutics position peaked at $6.96M in Q3 2021.
  • 33 funds tracked by Wall St. Rank held Seres Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.