Two Sigma Investments
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Two Sigma Investments’s BioLife Solutions BLFS Stock Holding History

Two Sigma Investments’s Portfolio BLFS Stock Details BLFS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-15,800
Closed -$403K – 4082
2025
Q3 		$403K Buy
+15,800
New +$375K ﹤0.01% 3087
2023
Q3 		– Sell
-27,000
Closed -$597K – 2961
2023
Q2 		$597K Sell
27,000
-7,200
-21% -$152K ﹤0.01% 2248
2023
Q1 		$744K Buy
34,200
+21,900
+178% +$493K ﹤0.01% 2025
2022
Q4 		$224K Buy
+12,300
New +$254K ﹤0.01% 2355
2022
Q2 		– Sell
-108,459
Closed -$2.46M – 2529
2022
Q1 		$2.46M Buy
+108,459
New +$2.86M 0.01% 1253
2021
Q3 		– Sell
-7,900
Closed -$352K – 4242
2021
Q2 		$352K Sell
7,900
-113,510
-93% -$4M ﹤0.01% 3374
2021
Q1 		$4.37M Buy
121,410
+92,310
+317% +$3.65M 0.01% 1145
2020
Q4 		$1.16M Buy
+29,100
New +$992K ﹤0.01% 1880
2020
Q3 		– Sell
-41,687
Closed -$682K – 3090
2020
Q2 		$682K Buy
+41,687
New +$575K ﹤0.01% 1782
2019
Q1 		– Sell
-62,468
Closed -$751K – 3024
2018
Q4 		$751K Sell
62,468
-43,369
-41% -$518K ﹤0.01% 1833
2018
Q3 		$1.85M Buy
105,837
+81,842
+341% +$1.62M 0.01% 1531
2018
Q2 		$274K Buy
23,995
+6,838
+40% +$62.3K ﹤0.01% 2995
2018
Q1 		$88K Buy
17,157
+757
+5% +$4.1K ﹤0.01% 3047
2017
Q4 		$98K Buy
+16,400
New +$94.5K ﹤0.01% 2995

Other funds holding BLFS

CC
Casdin Capital New York $1.32B AUM 76.62% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return
Invesco
Invesco Atlanta, Georgia $1.02T AUM 30.18% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
FAM
Fred Alger Management New York $22.8B AUM 64.63% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return
Massachusetts Financial Services
Massachusetts Financial Services Boston, Massachusetts $298B AUM 21.96% 1-Year Est. Return

Two Sigma Investments's BLFS Position: Q4 2025 in Review

Two Sigma Investments sold out of BioLife Solutions (BLFS) in Q4 2025, closing a stake of 15,800 shares — an estimated $403K sold.

Two Sigma Investments first reported a position in BLFS in Q4 2017 and held it in 14 quarters. The position peaked at $4.37M in Q1 2021. 187 funds tracked by Wall St. Rank hold BLFS as of Q4 2025.

  • Two Sigma Investments reported no remaining BioLife Solutions position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Investments sold 15,800 BioLife Solutions shares in Q4 2025, an estimated $403K.
  • Two Sigma Investments first reported a position in BioLife Solutions in Q4 2017 and held it in 14 quarters.
  • Two Sigma Investments's BioLife Solutions position peaked at $4.37M in Q1 2021.
  • 187 funds tracked by Wall St. Rank held BioLife Solutions as of Q4 2025.

Based on Two Sigma Investments's 13F filing for Q4 2025, filed 17 Feb 2026.