Two Sigma Investments
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Two Sigma Investments’s AYTU BioPharma AYTU Stock Holding History

Two Sigma Investments’s Portfolio AYTU Stock Details AYTU Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$333K Buy
121,973
+14,840
+14% +$37.9K ﹤0.01% 4006
2025
Q4 		$279K Buy
107,133
+38,397
+56% +$86.1K ﹤0.01% 3612
2025
Q3 		$129K Buy
68,736
+33,701
+96% +$77.9K ﹤0.01% 3436
2025
Q2 		$76.4K Buy
+35,035
New +$54.4K ﹤0.01% 3026
2023
Q1 		– Sell
-746
Closed -$2.82K – 2959
2022
Q4 		$2.82K Sell
746
-574
-43% -$2.16K ﹤0.01% 2762
2022
Q3 		$5K Sell
1,320
-724
-35% -$5.49K ﹤0.01% 2426
2022
Q2 		$28K Buy
+2,044
New +$26.2K ﹤0.01% 2381
2020
Q3 		– Sell
-487
Closed -$138K – 3070
2020
Q2 		$138K Buy
+487
New +$147K ﹤0.01% 2740

Other funds holding AYTU

NCM
Nantahala Capital Management New Canaan, Connecticut $2.72B AUM 121.58% 1-Year Est. Return
SCM
Stonepine Capital Management Bend, Oregon $250M AUM 77.6% 1-Year Est. Return
AIC
AWM Investment Company New York $903M AUM 163.47% 1-Year Est. Return
DP
Diadema Partners Morristown, New Jersey $588M AUM 182.75% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
CAM
Crown Advisors Management Larkspur, California $151M AUM 73.11% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
PAP
Persistent Asset Partners Hong Kong $268M AUM 158.98% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
VFT
Vanguard Fiduciary Trust Malvern, Pennsylvania $396B AUM

Two Sigma Investments's AYTU Position: Q1 2026 in Review

Two Sigma Investments increased its AYTU BioPharma (AYTU) stake by 14% in Q1 2026, buying an estimated $37.9K and bringing the position to 121,973 shares worth $333K. The position accounts for ﹤0.01% of the portfolio, ranked #4006.

Two Sigma Investments first reported a position in AYTU in Q2 2020 and has held it in 8 quarters since. 37 funds tracked by Wall St. Rank hold AYTU as of Q1 2026.

  • Two Sigma Investments held 121,973 shares of AYTU BioPharma worth $333K as of Q1 2026.
  • Two Sigma Investments bought 14,840 AYTU BioPharma shares in Q1 2026, an estimated $37.9K.
  • AYTU BioPharma made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4006 holding.
  • Two Sigma Investments first reported a position in AYTU BioPharma in Q2 2020 and has held it in 8 quarters since.
  • 37 funds tracked by Wall St. Rank held AYTU BioPharma as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.