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Two Sigma Advisers

Two Sigma Advisers Portfolio holdings

AUM $51.4B
1-Year Est. Return 31.07%
This Fund
S&P 500
This Quarter Est. Return
-3%
1 Year Est. Return
+31.07%
3 Year Est. Return
+128.94%
5 Year Est. Return
+161.75%
10 Year Est. Return
+607.04%
AUM
$44.4B
AUM Growth
+$1.2B
Cap. Flow
+$3.32B
Cap. Flow %
7.48%
Top 10 Hldgs %
17.65%
Holding
2,641
New
312
Increased
1,037
Reduced
994
Closed
281

Top Buys

Rank Stock Value
1
AVGO icon
Broadcom
AVGO
+$519M
2
CRM icon
Salesforce
CRM
+$460M
3
REGN icon
Regeneron Pharmaceuticals
REGN
+$381M
4
BSX icon
Boston Scientific
BSX
+$347M
5
ISRG icon
Intuitive Surgical
ISRG
+$319M

Top Sells

Rank Stock Value
1
V icon
Visa
V
+$555M
2
LLY icon
Eli Lilly
LLY
+$536M
3
META icon
Meta Platforms (Facebook)
META
+$433M
4
PGR icon
Progressive
PGR
+$330M
5
LRCX icon
Lam Research
LRCX
+$294M

Sector Composition

Rank Sector Weight
1 Technology 25.86%
2 Healthcare 15.38%
3 Financials 14.3%
4 Consumer Discretionary 11.43%
5 Industrials 10.56%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
HBIO icon
2276
Harvard Bioscience
HBIO
$26.9M
$76.7K ﹤0.01%
13,556
+10,700
+375% +$137K
IMNM icon
2277
Immunome
IMNM
$2.6B
$76.7K ﹤0.01%
11,400
-36,800
-76% -$353K
HUMA icon
2278
Humacyte
HUMA
$167M
$76K ﹤0.01%
44,600
-102,500
-70% -$385K
HOWL icon
2279
Werewolf Therapeutics
HOWL
$22.9M
$74.9K ﹤0.01%
77,000
-62,100
-45% -$81.3K
PSNL icon
2280
Personalis
PSNL
$1.24B
$73K ﹤0.01%
20,800
-13,500
-39% -$64.2K
WHWK
2281
Whitehawk Therapeutics
WHWK
$181M
$72.9K ﹤0.01%
40,969
-20,717
-34% -$54.1K
CDLX icon
2282
Cardlytics
CDLX
$22M
$71.2K ﹤0.01%
3,910
+220
+6% +$6.28K
TRUE
2283
DELISTED
TrueCar
TRUE
$70K ﹤0.01%
44,300
+11,300
+34% +$31.4K
RLX icon
2284
RLX Technology
RLX
$2.38B
$69.9K ﹤0.01%
37,200
-18,700
-33% -$41.5K
ORN icon
2285
Orion Group Holdings
ORN
$357M
$69K ﹤0.01%
+13,200
New +$92.3K
ULBI icon
2286
Ultralife
ULBI
$89.1M
$68.9K ﹤0.01%
+12,800
New +$87K
SGHC icon
2287
SGHC Ltd
SGHC
$7.63B
$68.3K ﹤0.01%
+10,600
New +$76.1K
CLOV icon
2288
Clover Health Investments
CLOV
$2.23B
$67.9K ﹤0.01%
18,900
-5,800
-23% -$23.3K
TCRX icon
2289
TScan Therapeutics
TCRX
$48.6M
$67.6K ﹤0.01%
+49,000
New +$106K
HCAT icon
2290
Health Catalyst
HCAT
$157M
$67K ﹤0.01%
14,800
-14,900
-50% -$78.8K
GENK icon
2291
GEN Restaurant Group
GENK
$10.7M
$66.2K ﹤0.01%
12,000
-1,300
-10% -$8.06K
MREO
2292
Mereo BioPharma
MREO
$50.3M
$65.9K ﹤0.01%
+29,300
New +$82.9K
BGFV
2293
DELISTED
Big 5 Sporting Goods
BGFV
$65.7K ﹤0.01%
68,000
-15,900
-19% -$21.8K
BCAB icon
2294
BioAtla
BCAB
$5.46M
$65.5K ﹤0.01%
3,778
+2,548
+207% +$54.5K
ONL
2295
Orion Office REIT
ONL
$149M
$64.4K ﹤0.01%
30,100
-69,900
-70% -$244K
REAX icon
2296
Real Brokerage
REAX
$353M
$64.1K ﹤0.01%
15,800
-6,300
-29% -$29.9K
GSIT icon
2297
GSI Technology
GSIT
$202M
$63.9K ﹤0.01%
31,500
+20,500
+186% +$59.9K
NAK
2298
Northern Dynasty Minerals
NAK
$779M
$63.6K ﹤0.01%
55,300
-85,600
-61% -$62.3K
CCO icon
2299
Clear Channel Outdoor Holdings
CCO
$1.22B
$63.4K ﹤0.01%
57,100
-63,715
-53% -$84.1K
CMPS
2300
Compass Pathways
CMPS
$1.46B
$62.9K ﹤0.01%
22,000
-19,500
-47% -$74.9K
90 91
92
93 94

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Two Sigma Advisers's Q1 2025 Portfolio in Review

As of Q1 2025, Two Sigma Advisers held 2,641 positions worth $44.4B, up 2.8% from $43.2B the previous quarter. Its ten largest holdings account for 18% of the portfolio.

Two Sigma Advisers deployed $3.32B of net new capital in Q1 2025, opening 312 new positions and adding to 1,037 existing holdings. Its largest new stake was Regeneron Pharmaceuticals: 553,800 shares worth $351M.

By sector, the portfolio is most concentrated in Technology at 26% of assets, up from 25% a quarter earlier, followed by Healthcare and Financials.

On the sell side, the largest reduction was Visa, an estimated $555M trimmed.

  • Two Sigma Advisers's largest Q1 2025 buy was Regeneron Pharmaceuticals: 553,800 shares worth $351M.
  • Two Sigma Advisers added most to Broadcom in Q1 2025, an estimated $519M increase.
  • Two Sigma Advisers's biggest Q1 2025 reduction was Visa, cutting an estimated $555M.
  • Two Sigma Advisers fully exited Abbott in Q1 2025, selling an estimated $158M.
  • Two Sigma Advisers's ten largest holdings make up 18% of its $44.4B portfolio in Q1 2025.
  • Two Sigma Advisers opened 312 new positions and closed 281 in Q1 2025.
  • Two Sigma Advisers's portfolio value rose 2.8% quarter-over-quarter to $44.4B.

Based on Two Sigma Advisers's 13F filing for Q1 2025, filed 15 May 2025.