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Two Sigma Advisers

Two Sigma Advisers Portfolio holdings

AUM $51.4B
1-Year Est. Return 31.07%
This Fund
S&P 500
This Quarter Est. Return
-3%
1 Year Est. Return
+31.07%
3 Year Est. Return
+128.94%
5 Year Est. Return
+161.75%
10 Year Est. Return
+607.04%
AUM
$44.4B
AUM Growth
+$1.2B
Cap. Flow
+$3.32B
Cap. Flow %
7.48%
Top 10 Hldgs %
17.65%
Holding
2,641
New
312
Increased
1,037
Reduced
994
Closed
281

Top Buys

Rank Stock Value
1
AVGO icon
Broadcom
AVGO
+$519M
2
CRM icon
Salesforce
CRM
+$460M
3
REGN icon
Regeneron Pharmaceuticals
REGN
+$381M
4
BSX icon
Boston Scientific
BSX
+$347M
5
ISRG icon
Intuitive Surgical
ISRG
+$319M

Top Sells

Rank Stock Value
1
V icon
Visa
V
+$555M
2
LLY icon
Eli Lilly
LLY
+$536M
3
META icon
Meta Platforms (Facebook)
META
+$433M
4
PGR icon
Progressive
PGR
+$330M
5
LRCX icon
Lam Research
LRCX
+$294M

Sector Composition

Rank Sector Weight
1 Technology 25.86%
2 Healthcare 15.38%
3 Financials 14.3%
4 Consumer Discretionary 11.43%
5 Industrials 10.56%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SLN
2201
Silence Therapeutics
SLN
$555M
$139K ﹤0.01%
49,200
-49,600
-50% -$242K
BLFY
2202
DELISTED
Blue Foundry Bancorp
BLFY
$138K ﹤0.01%
15,000
+2,500
+20% +$23.9K
ZIMV
2203
DELISTED
ZimVie
ZIMV
$136K ﹤0.01%
12,600
-200
-2% -$2.63K
SOHU
2204
Sohu.com
SOHU
$355M
$133K ﹤0.01%
10,100
-100
-1% -$1.34K
TNGX icon
2205
Tango Therapeutics
TNGX
$4.26B
$133K ﹤0.01%
97,000
+70,800
+270% +$174K
NMRK icon
2206
Newmark Group
NMRK
$2.69B
$133K ﹤0.01%
+10,900
New +$145K
TRVG
2207
trivago
TRVG
$389M
$132K ﹤0.01%
32,196
-2,800
-8% -$10.3K
PETS icon
2208
PetMed Express
PETS
$42.7M
$130K ﹤0.01%
31,100
-12,900
-29% -$58.6K
VFF icon
2209
Village Farms International
VFF
$241M
$129K ﹤0.01%
212,700
+19,700
+10% +$14.4K
NN icon
2210
NextNav
NN
$1.8B
$128K ﹤0.01%
+10,500
New +$127K
OMER icon
2211
Omeros
OMER
$850M
$127K ﹤0.01%
15,500
-23,300
-60% -$206K
LFST icon
2212
Lifestance Health
LFST
$4.22B
$127K ﹤0.01%
19,000
-5,800
-23% -$44.1K
ITUB icon
2213
Itaú Unibanco
ITUB
$90.8B
$126K ﹤0.01%
+23,587
New +$119K
RMAX icon
2214
RE/MAX Holdings
RMAX
$198M
$125K ﹤0.01%
14,900
-2,400
-14% -$22.9K
STGW icon
2215
Stagwell
STGW
$2.01B
$123K ﹤0.01%
+20,400
New +$128K
NVRI icon
2216
Enviri
NVRI
$629M
$122K ﹤0.01%
18,400
-5,600
-23% -$44K
PGEN icon
2217
Precigen
PGEN
$1.98B
$122K ﹤0.01%
81,700
-10,900
-12% -$17.2K
PACB icon
2218
Pacific Biosciences
PACB
$441M
$121K ﹤0.01%
102,500
-65,400
-39% -$100K
ARHS icon
2219
Arhaus
ARHS
$1.09B
$121K ﹤0.01%
13,900
-1,200
-8% -$12.8K
RAPP
2220
Rapport Therapeutics
RAPP
$1.99B
$120K ﹤0.01%
+12,000
New +$156K
OKUR
2221
OnKure Therapeutics
OKUR
$162M
$119K ﹤0.01%
27,628
+13,400
+94% +$75.4K
AMPX icon
2222
Amprius Technologies
AMPX
$1.25B
$118K ﹤0.01%
44,100
-1,600
-4% -$4.72K
XPER icon
2223
Xperi
XPER
$367M
$117K ﹤0.01%
15,100
+600
+4% +$5.25K
NESR
2224
National Energy Services Reunited Corp
NESR
$2.51B
$116K ﹤0.01%
15,700
+1,500
+11% +$12.9K
RSVR icon
2225
Reservoir Media
RSVR
$727M
$115K ﹤0.01%
15,100
-2,100
-12% -$16.5K
87 88
89
90 91

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Two Sigma Advisers's Q1 2025 Portfolio in Review

As of Q1 2025, Two Sigma Advisers held 2,641 positions worth $44.4B, up 2.8% from $43.2B the previous quarter. Its ten largest holdings account for 18% of the portfolio.

Two Sigma Advisers deployed $3.32B of net new capital in Q1 2025, opening 312 new positions and adding to 1,037 existing holdings. Its largest new stake was Regeneron Pharmaceuticals: 553,800 shares worth $351M.

By sector, the portfolio is most concentrated in Technology at 26% of assets, up from 25% a quarter earlier, followed by Healthcare and Financials.

On the sell side, the largest reduction was Visa, an estimated $555M trimmed.

  • Two Sigma Advisers's largest Q1 2025 buy was Regeneron Pharmaceuticals: 553,800 shares worth $351M.
  • Two Sigma Advisers added most to Broadcom in Q1 2025, an estimated $519M increase.
  • Two Sigma Advisers's biggest Q1 2025 reduction was Visa, cutting an estimated $555M.
  • Two Sigma Advisers fully exited Abbott in Q1 2025, selling an estimated $158M.
  • Two Sigma Advisers's ten largest holdings make up 18% of its $44.4B portfolio in Q1 2025.
  • Two Sigma Advisers opened 312 new positions and closed 281 in Q1 2025.
  • Two Sigma Advisers's portfolio value rose 2.8% quarter-over-quarter to $44.4B.

Based on Two Sigma Advisers's 13F filing for Q1 2025, filed 15 May 2025.